CAJ | 학술논문

目的分析p27蛋白表达与结直肠癌临床病理特征的关系.方法应用免疫组化SABC法,检测44例结直肠癌癌中心、癌旁(距肿瘤边缘1cm)、癌切缘(距肿瘤边缘3cm以上)p27蛋白表达情况,并分析P27蛋白表达与结直肠癌临床病理特征的关系.结果 44例结直肠癌癌中心p27蛋白表达为56.82%(25/44),癌旁黏膜为88.64%(39/44),癌切缘为97.73%(43/44);p27蛋白表达与年龄、性别、肿瘤部位及大小无显著相关,而与肿瘤临床分期、分化程度及淋巴结转移显著相关.结论 p27蛋白的表达与结直肠癌的部分临床病理特征密切相关,可能是判断结直肠癌预后的一项重要指标.
목적 분석p27단백표체여결직장암림상병리특정적관계.방법 응용면역조화SABC법,검측44례결직장암암중심、암방(거종류변연1cm)、암절연(거종류변연3cm이상)p27단백표체정황,병분석P27단백표체여결직장암림상병리특정적관계.결과 44례결직장암암중심p27단백표체위56.82%(25/44),암방점막위88.64%(39/44),암절연위97.73%(43/44);p27단백표체여년령、성별、종류부위급대소무현저상관,이여종류림상분기、분화정도급림파결전이현저상관.결론 p27단백적표체여결직장암적부분림상병리특정밀절상관,가능시판단결직장암예후적일항중요지표.
Objective To investigate the significance of p27 expression in colorectal carcinomas (CRCs). Methods The samples were obtained from 44 cases. P27 expression was detected by immunohistochemistry using the SABC staining method at the three sites: carcinoma tissue, pericarcinoma (1 cm away from CRC) and the incision margin (3 cm away from CRC). Results Expression of p27 was found in 56.82% (25/44) of CRCs, in 88.64% (39/44) of percarcinoma and and in 97.73%(43/44) of the mucosa at the incison margin. P27 expression in CRCs was correlated significantly with Dukes stage (P<0.05), histology grade (P<0.01) and local lymph node involvement (P<0.05), but not with age, gender, and site or size of the CRC.Conclusion The decrease of p27 expression may be involved in the malignant transformation of colorectal epithelial cells to CRC. Expression of p27 in CRC correlates with some clinicopathological characteristics and may be of prognostic significance.