化学物理学报
化學物理學報
화학물이학보
CHINESE JOURNAL OF CHEMICAL PHYSICS
2006年
5期
423-427
,共5页
刘晓红%许芳%张奕%刘丽红%黄华容%佘志刚%林永成%陈荣礼
劉曉紅%許芳%張奕%劉麗紅%黃華容%佘誌剛%林永成%陳榮禮
류효홍%허방%장혁%류려홍%황화용%사지강%림영성%진영례
3S-7-羟基蜂蜜曲霉素%分离%晶体结构
3S-7-羥基蜂蜜麯黴素%分離%晶體結構
3S-7-간기봉밀곡매소%분리%정체결구
3S-hydroxy-7 melleine%Isolation%Crystal structure
从红树林内生真菌Xylariasp.2508中分离到一个新的蜂蜜曲霉素型化合物3S-7-羟基蜂蜜曲霉素,这是首次从海洋真菌中获得该类结构的化合物并测定其晶体结构.通过核磁共振谱、红外光谱、质谱进行结构鉴定.其单晶经X射线衍射测试表明,该化合物晶体属单斜晶系,空间群为P21,化学式为C10H12O5,Mr=212.20.晶胞参数为:a=10.8884(19)(A),b=7.2284(13)(A),c=13.398(2)(A),β=104.217(3)°,V=1022.2(3)(A)3,Z=4,Dc=1.379 mg/m3,F(000)=448,μ=0.112 mm-1.结构由直接法解出,用全矩阵最小二乘法修正,最终偏离因子R=0.0498,wR=0.101.该分子由一个苯并吡喃环组成.通过与文献中已知3R-7-羟基蜂蜜曲霉素的熔点及旋光度对照,确定其绝对构型为3S.其初步抑菌实验结果表明,3S-7-羟基蜂蜜曲霉素菌在每纸片200 μg的剂量下对金黄色葡萄球菌(Staphylococcus aureus)没有表现出抑菌活性.
從紅樹林內生真菌Xylariasp.2508中分離到一箇新的蜂蜜麯黴素型化閤物3S-7-羥基蜂蜜麯黴素,這是首次從海洋真菌中穫得該類結構的化閤物併測定其晶體結構.通過覈磁共振譜、紅外光譜、質譜進行結構鑒定.其單晶經X射線衍射測試錶明,該化閤物晶體屬單斜晶繫,空間群為P21,化學式為C10H12O5,Mr=212.20.晶胞參數為:a=10.8884(19)(A),b=7.2284(13)(A),c=13.398(2)(A),β=104.217(3)°,V=1022.2(3)(A)3,Z=4,Dc=1.379 mg/m3,F(000)=448,μ=0.112 mm-1.結構由直接法解齣,用全矩陣最小二乘法脩正,最終偏離因子R=0.0498,wR=0.101.該分子由一箇苯併吡喃環組成.通過與文獻中已知3R-7-羥基蜂蜜麯黴素的鎔點及鏇光度對照,確定其絕對構型為3S.其初步抑菌實驗結果錶明,3S-7-羥基蜂蜜麯黴素菌在每紙片200 μg的劑量下對金黃色葡萄毬菌(Staphylococcus aureus)沒有錶現齣抑菌活性.
종홍수림내생진균Xylariasp.2508중분리도일개신적봉밀곡매소형화합물3S-7-간기봉밀곡매소,저시수차종해양진균중획득해류결구적화합물병측정기정체결구.통과핵자공진보、홍외광보、질보진행결구감정.기단정경X사선연사측시표명,해화합물정체속단사정계,공간군위P21,화학식위C10H12O5,Mr=212.20.정포삼수위:a=10.8884(19)(A),b=7.2284(13)(A),c=13.398(2)(A),β=104.217(3)°,V=1022.2(3)(A)3,Z=4,Dc=1.379 mg/m3,F(000)=448,μ=0.112 mm-1.결구유직접법해출,용전구진최소이승법수정,최종편리인자R=0.0498,wR=0.101.해분자유일개분병필남배조성.통과여문헌중이지3R-7-간기봉밀곡매소적용점급선광도대조,학정기절대구형위3S.기초보억균실험결과표명,3S-7-간기봉밀곡매소균재매지편200 μg적제량하대금황색포도구균(Staphylococcus aureus)몰유표현출억균활성.
A new compound, 3S-hydroxy-7 melleine was isolated from the endophytic fungus Xylariasp No.2508 from the mangrove tree on the South China Sea coast. It was the first time that this kind of compound was isolated from marine fungus. The structure was elucidated by NMR data, infrared spectrum (IR) and mass spectrometry (MS). In addition, its structure was determined by the single-crystal X-ray diffraction analysis. It crystallized in monoclinic, space group P21 with a=10.8884(19) (A), b=7.2284(13) (A), c=13.398(2) (A), β=104.217(3)°,C10H10O4·H2O, Mr=212.20, V=1022.2(3) (A)3, Z=4, Dc=1.379 mg/m3, F(000)=448, μ=0.112 mm-1, the final R=0.0498, wR=0.101 for 2407 observed reflections (I>2σ(I)). The molecular backbone of the compound includes a benzopyran ring. By comparing with the melting point and the optical rotation of the known 3R-hydroxy-7 melleine in literature, the absolute configuration of the compound was determined as 3S. It didn't exhibit antibacterial activity against Gram-positive bacterium Staphylococcus aureus at 200μg/disk in the preliminary test.