CAJ | 학술논문

目的探讨曲唑酮对老年苯二氮卓类药物(BZD)依赖患者替代治疗的疗效及对认知功的影响.方法对51例老年BZD依赖患者采用剂量快速递减、曲唑酮替代疗法,14d内停用BZD,之后睡前顿服曲唑酮,连服6个月.采用匹兹堡睡眠质量指数(PSQJ)量表和副反应量表(TESS)评定临床疗效和不良反应.选用韦氏成人智力量表( WAIS-RC)、韦氏成人记忆量表(WMS-RC)评定认知功能.疗效和不良反应于治疗前后评定；认知功能于治疗前后各评定1次.结果 PSQJ总分[(13.17 ±3.70)分,(11.05±3.48)分]、睡眠质量[(2.36±0.33)分,(1.91 ±0.29)分]、睡眠障碍、日间功能障碍分疗后低于疗前(P＜0.05),其他成份分无差异.曲唑酮副反应少而轻,更无依赖发生.认知功能中的知识、算术、数字符号、木块拼图、长时记忆、短时记忆、即刻记忆及记忆商数分方面疗前均低于疗后(P＜0.05).结论曲唑酮可作为老年失眠患者的理想药物.
목적 탐토곡서동대노년분이담탁류약물(BZD)의뢰환자체대치료적료효급대인지공적영향.방법 대51례노년BZD의뢰환자채용제량쾌속체감、곡서동체대요법,14d내정용BZD,지후수전돈복곡서동,련복6개월.채용필자보수면질량지수(PSQJ)량표화부반응량표(TESS)평정림상료효화불량반응.선용위씨성인지역량표( WAIS-RC)、위씨성인기억량표(WMS-RC)평정인지공능.료효화불량반응우치료전후평정；인지공능우치료전후각평정1차.결과 PSQJ총분[(13.17 ±3.70)분,(11.05±3.48)분]、수면질량[(2.36±0.33)분,(1.91 ±0.29)분]、수면장애、일간공능장애분료후저우료전(P＜0.05),기타성빈분무차이.곡서동부반응소이경,경무의뢰발생.인지공능중적지식、산술、수자부호、목괴병도、장시기억、단시기억、즉각기억급기억상수분방면료전균저우료후(P＜0.05).결론 곡서동가작위노년실면환자적이상약물.
Objective To explore the efficacy of trazodone replacement treatment on benzodiazepine drugs dependence and effect of cognitive function on senile patients.Methods 51 senile patients with benzodiazepine drugs dependence were assigned with dosage tacho-decrement and replaced by trazodone.The patients were discontinuanced taking benzodiazepine in 14 days and taken at a draught of trazodone before retiring about 6 months.Clinical effect and side effects were assessed with the Pittsburgh sleep quality index (PSQJ) and treatment emergent symptom scale(TESS) before and after treatment.Cognitive function was evaluated with Wechsler intelligence scale for adult-Chinese revised (WAIS-RC) and Wechsler mermory scale for adult-Chinese revised ( WMS-RC ) once before and after treatment.Results The scores total PSQJ( ( 13.17 ± 3.70),( 11.05 ± 3.48 ) ),the sleep quality( (2.36 ± 0.33 ),( 1.91 ± 0.29 ) ),daily function disorder,sleep disorder were significantly lower than before treatment while the other factor scores were not significantly changed.Trazodone wes effective without severe side effects and dependence.The study group showed significantly lower scores in learning,calculation,the signs of figure,wood puzzles,long-term memory,short-term memory,immediate memory,memory quotient in the assessment of cognitive function than after treatmemt (P ＜ 0.05 ).Conclusion Trazodone is an ideal medicine to senile insomnia.