CAJ | 학술논문

目的探讨甲硫腺苷磷酸化酶(MTAP)基因单核苷酸多态性(SNP)与中国汉族人群心肌梗死(MI)的关系.方法选取432例初发MI患者及430例同期住院的外科对照患者.选取MTAP基因9个标签SNP,采用PCR-SNP Stream技术对所选标签SNP位点进行分型.并对分型结果进行统计学分析.结果在总体样本中未发现所选SNP位点与MI患病存在关联,经性别分层后,在男性组rs7027989位点的G等位基因在MI组分布频率增高,差异有统计学意义(P=0.003);在显性遗传模型中,GG基因型较AG+AA基因型的男性对象患MI的风险增加了26%,差异有统计学意义(P=0.005),经校正混杂因素后其统计学显著性仍然存在.结论 MTAP基因同汉族人群MI患病相关.
목적 탐토갑류선감린산화매(MTAP)기인단핵감산다태성(SNP)여중국한족인군심기경사(MI)적관계.방법 선취432례초발MI환자급430례동기주원적외과대조환자.선취MTAP기인9개표첨SNP,채용PCR-SNP Stream기술대소선표첨SNP위점진행분형.병대분형결과진행통계학분석.결과재총체양본중미발현소선SNP위점여MI환병존재관련,경성별분층후,재남성조rs7027989위점적G등위기인재MI조분포빈솔증고,차이유통계학의의(P=0.003);재현성유전모형중,GG기인형교AG+AA기인형적남성대상환MI적풍험증가료26%,차이유통계학의의(P=0.005),경교정혼잡인소후기통계학현저성잉연존재.결론 MTAP기인동한족인군MI환병상관.
Objective To investigate the association between methylthioadenosine phosphorylase (MTAP) gene single nucleotide polymorphisms (SNP) and myocardial infarction (MI) in the Chinese Han ethnicity. Methods 432 patients suffered from myocardial infarction and 430 controls were involved for case and control groups, respectively. Nine tag SNPs in MTAP gene were selected and genotyped. Results We found no significant association of selected tag SNPs with MI in all of the samples. However, in stratified analysis, significant association was observed at rs7027989 in male subjects. The risk of MI increased by 26% (P=0.005) for male subjects of minor allele carriers in a dominant model. The increased risk of MI at rs7027989 remained significant after adjusting for confounding factors. Conclusion MTAP gene might be involved in the etiology of MI in Chinese Han ethnicity.