CAJ | 학술논문

目的:总结胶质细胞源性神经营养因子对神经组织缺血性损伤的影响,以及微囊化技术发展情况,探讨该种营养因子用于脊髓损伤修复的可能性.资料来源:检索Medline 1996-01/2000-10与胶质细胞源性神经营养因子和神经组织缺血性损伤、脊髓损伤及其与微囊化技术相关的文章,检索词"glial cell line-derived neurotrophicfactor,ischemia damageto nervetissue,spinal cord injury",并限定文章语言种类为English.检索万方数据库2001-01/2004-10胶质细胞源性神经营养因子与神经组织缺血性损伤、脊髓损伤关系及其与微囊化技术相关,限定文章语言种类为中文,检索词"胶质细胞源性神经营养因子,神经组织缺血性损伤,脊髓损伤,微囊化技术". 资料选择:对资料进行初审,选取包括处理组和对照组的文献,根据数据库文献摘要提供的信息,筛除明显不随机的研究,对剩余的文献开始查找全文.纳入标准为①随机对照研究;②实验或临床研究包含平行对照组.排除标准:重复性研究.资料提炼:共收集到300篇关于胶质细胞源性神经营养因子与缺血性损伤和脊髓损伤的随机和未随机研究文章,15个实验或临床研究符合纳人标准.排除的285篇文章中,264篇为未随机研究或重复性研究,21篇为综述类文章.资料综合:胶质细胞源性神经营养因子对大鼠中脑多巴胺能神经元有营养支持作用;可使多巴胺神经元细胞死亡减少,轴突再生.胶质细胞源性神经营养因子可使脑梗死大鼠大脑半球免于自由基、钙超载等缺血性损伤,阻止缺血后一氧化氮的产生及再灌注损伤,是对抗缺血性损伤的有效保护因子.微囊化技术在内分泌疾病和神经系统疾病等治疗方面,显示出良好前景,营养因子可能在微囊化技术中发展重要作用.结论:胶质细胞源性神经营养因子对神经组织缺血性损伤起到保护作用,微囊化技术的发展促进该种营养因子发挥作用;胶质细胞源性神经营养因子在临床脊髓修复方面具有良好前景. 目的:總結膠質細胞源性神經營養因子對神經組織缺血性損傷的影響,以及微囊化技術髮展情況,探討該種營養因子用于脊髓損傷脩複的可能性.資料來源:檢索Medline 1996-01/2000-10與膠質細胞源性神經營養因子和神經組織缺血性損傷、脊髓損傷及其與微囊化技術相關的文章,檢索詞"glial cell line-derived neurotrophicfactor,ischemia damageto nervetissue,spinal cord injury",併限定文章語言種類為English.檢索萬方數據庫2001-01/2004-10膠質細胞源性神經營養因子與神經組織缺血性損傷、脊髓損傷關繫及其與微囊化技術相關,限定文章語言種類為中文,檢索詞"膠質細胞源性神經營養因子,神經組織缺血性損傷,脊髓損傷,微囊化技術". 資料選擇:對資料進行初審,選取包括處理組和對照組的文獻,根據數據庫文獻摘要提供的信息,篩除明顯不隨機的研究,對剩餘的文獻開始查找全文.納入標準為①隨機對照研究;②實驗或臨床研究包含平行對照組.排除標準:重複性研究.資料提煉:共收集到300篇關于膠質細胞源性神經營養因子與缺血性損傷和脊髓損傷的隨機和未隨機研究文章,15箇實驗或臨床研究符閤納人標準.排除的285篇文章中,264篇為未隨機研究或重複性研究,21篇為綜述類文章.資料綜閤:膠質細胞源性神經營養因子對大鼠中腦多巴胺能神經元有營養支持作用;可使多巴胺神經元細胞死亡減少,軸突再生.膠質細胞源性神經營養因子可使腦梗死大鼠大腦半毬免于自由基、鈣超載等缺血性損傷,阻止缺血後一氧化氮的產生及再灌註損傷,是對抗缺血性損傷的有效保護因子.微囊化技術在內分泌疾病和神經繫統疾病等治療方麵,顯示齣良好前景,營養因子可能在微囊化技術中髮展重要作用.結論:膠質細胞源性神經營養因子對神經組織缺血性損傷起到保護作用,微囊化技術的髮展促進該種營養因子髮揮作用;膠質細胞源性神經營養因子在臨床脊髓脩複方麵具有良好前景.
목적:총결효질세포원성신경영양인자대신경조직결혈성손상적영향,이급미낭화기술발전정황,탐토해충영양인자용우척수손상수복적가능성.자료래원:검색Medline 1996-01/2000-10여효질세포원성신경영양인자화신경조직결혈성손상、척수손상급기여미낭화기술상관적문장,검색사"glial cell line-derived neurotrophicfactor,ischemia damageto nervetissue,spinal cord injury",병한정문장어언충류위English.검색만방수거고2001-01/2004-10효질세포원성신경영양인자여신경조직결혈성손상、척수손상관계급기여미낭화기술상관,한정문장어언충류위중문,검색사"효질세포원성신경영양인자,신경조직결혈성손상,척수손상,미낭화기술". 자료선택:대자료진행초심,선취포괄처리조화대조조적문헌,근거수거고문헌적요제공적신식,사제명현불수궤적연구,대잉여적문헌개시사조전문.납입표준위①수궤대조연구;②실험혹림상연구포함평행대조조.배제표준:중복성연구.자료제련:공수집도300편관우효질세포원성신경영양인자여결혈성손상화척수손상적수궤화미수궤연구문장,15개실험혹림상연구부합납인표준.배제적285편문장중,264편위미수궤연구혹중복성연구,21편위종술류문장.자료종합:효질세포원성신경영양인자대대서중뇌다파알능신경원유영양지지작용;가사다파알신경원세포사망감소,축돌재생.효질세포원성신경영양인자가사뇌경사대서대뇌반구면우자유기、개초재등결혈성손상,조지결혈후일양화담적산생급재관주손상,시대항결혈성손상적유효보호인자.미낭화기술재내분비질병화신경계통질병등치료방면,현시출량호전경,영양인자가능재미낭화기술중발전중요작용.결론:효질세포원성신경영양인자대신경조직결혈성손상기도보호작용,미낭화기술적발전촉진해충영양인자발휘작용;효질세포원성신경영양인자재림상척수수복방면구유량호전경.
OBJECTIVE: To summarize the effects of glial cell line-derived neurotrophic factor (GDNF) on ischemia damage to nerve tissue and discuss the possibility of GDNF in repair of spinal cord injury based on the development of microencapsulation technology.DATA SOURCES: A search of Medline from January 1996 to October 2000 was performed for the English articles related to GDNF, ischemia damage to nerve tissue, spinal cord injury and microencapsulation technology by using the key words "glial cell line-derived neurotrophic factor, ischemia damage to nerve tissue, spinal cord injury". Meanwhile, we retrieved Wangfang database for search of the related articles in Chinese by using the same keywords in Chinese.STUDY SELECTION: Articles including intervention group and control group were selected after first review, and those which were significantly non-randomized researches were excluded. Then, the full-texts of the enrolled articles were retrieved. Inclusion criteria: ①randomized controlled study; ②the experiment/clinical research including horizontal control group. Exclusion criteria: duplicated researches.DATA EXTRACTION: Totally 300 articles were selected but only 15 were in coincidence with conclusion criteria. 285 articles were excluded, 264 of them were duplicated and non-randomized researches, and 21 were review articles.DATA SYNTHESIS: GDNF can provide nutrition to dopamine nerve cell in rat's middle brain, so as to decrease dopamine nerve cell's death. Also GDNF can protect dopamine nerve cell in cerebral infarction rats from ischemic injury, inhibit the produce of nitrogen monoxide and reperfusion injury after ischemia. GDNF is an effective protective factor against ischemia damage. Microencapsulation technology has a bright future in treating endocrinopathic neural diseases, and GDNF can play a great role in the development of microencapsulation technology.CONCLUSION: GDNF is a protective factor against ischemia damage to nerve tissue, which can be enhanced by microencapsulation technology.There is a bright future for the research on GDNF in the clinical repair of spinal cord injury.