CAJ | 학술논문

目的:研究胰岛素治疗中三种不同血糖控制目标对危重颅脑疾病病人蛋白质代谢的影响.方法:将122例危重颅脑疾病病人随机分为三组,分别给予胰岛素控制血糖于不同的目标,即A组41例,血糖控制在4.4～6.1 mmol/L);B组42例,血糖控制在6.1～8.3 mmol/L,C组39例,血糖控制在10～11.1 mmol/L.对三组病人的蛋白质代谢情况和低血糖发生率进行比较.结果:A组与B组氮平衡、PA和TF指标优于C组,差异有显著性意义(P<0.05);但低血糖发生率A组高于B组和C组(P<0.05).结论:病人血糖控制在≤8.3 mmol/L,有利于减轻严重颅脑疾病病人的高分解代谢,促进蛋白合成,改善营养状况.
목적:연구이도소치료중삼충불동혈당공제목표대위중로뇌질병병인단백질대사적영향.방법:장122례위중로뇌질병병인수궤분위삼조,분별급여이도소공제혈당우불동적목표,즉A조41례,혈당공제재4.4～6.1 mmol/L);B조42례,혈당공제재6.1～8.3 mmol/L,C조39례,혈당공제재10～11.1 mmol/L.대삼조병인적단백질대사정황화저혈당발생솔진행비교.결과:A조여B조담평형、PA화TF지표우우C조,차이유현저성의의(P<0.05);단저혈당발생솔A조고우B조화C조(P<0.05).결론:병인혈당공제재≤8.3 mmol/L,유리우감경엄중로뇌질병병인적고분해대사,촉진단백합성,개선영양상황.
Objective: To investigate the effect of three different goals of blood glucose control by insulin therapy on protein metabolism in the patients with critically cerebral disease.Methods: We performed a prospective,randomized,controlled study.A total of 122 patients with critically cerebral disease were randomly divided into three groups according to the target glucose-control levels:Group A: 4.4-6.1 mmol/L(n=41),Group B: 6.1-8.3 mmol/L(n=42),and Group C: 10-11.1 mmol/L(n=39).The state of protein metabolism and ratio of hypoglycemia of three groups were compared.Results: The indicators of nitrogen balance,prealbumin and transferrin in group A and group B were significantly better than that in group C(P<0.05),but the ratio of hypoglycemia in group A was significantly higher than those in group B and group C(P<0.05).Conclusion: Maintaining the blood glucose level ≤8.3 mmol/L might improve the nutrition status in the patients with critically cerebral disease by decreasing catabolism and promoting synthesis of protein.