CAJ | 학술논문

Hedgehog(Hh)信号通路在脊椎动物胚胎发育过程中起核心作用,参与调控多个基本生命过程,包括细胞增殖、分化和组织塑形.在正常成人该通路涉及干细胞维持、组织修复和再生等过程.目前越来越多的证据表明Hh信号通路与人类肿瘤的增殖、生存能力等有相关性.
Hedgehog(Hh)신호통로재척추동물배태발육과정중기핵심작용,삼여조공다개기본생명과정,포괄세포증식、분화화조직소형.재정상성인해통로섭급간세포유지、조직수복화재생등과정.목전월래월다적증거표명Hh신호통로여인류종류적증식、생존능력등유상관성.
The Hedgehog (Hh) signaling pathway plays a central important role during embryo development of vertebrate,which participates in regulation of multiple basic life processes including cell proliferation,differentiation and tissue patterning.In normal adult physiology,the pathway is implicated in stem cell maintenance,tissue repair and regeneration.By now,more and more researches have been indicated that the Hh signaling pathway is related to the tumor growth promoting and survival capabilities.