中国地方病学杂志
中國地方病學雜誌
중국지방병학잡지
CHINESE JOURNAL OF ENDEMIOLOGY
2008年
6期
694-696
,共3页
目的 观察自身免疫性甲状腺疾病(AITD)患者血清Ⅲ型前胶原(PCⅢ)和透明质酸(HA)水平.探讨其临床意义.方法 按甲状腺功能将114例AITD患者分为3组:①Graves病甲状腺功能亢进(简称甲亢)组(38例),②桥本甲状腺炎甲状腺功能低下(简称甲低)组(35例),③桥本甲状腺炎亚临床甲状腺功能低下(简称哑甲低)组(41例),另设40例健康人作为对照组.用免疫化学发光法检测以上各组人群血清游离三碘甲腺原氨酸(FT3),游离甲状腺素(FT4),超敏促甲状腺激素(sTSH)水平.用酶联免疫吸附试验(ELISA)检测血清PCⅢ水平,用放射免疫分析法(RIA)检测血清HA水平.结果 甲亢组血清FT3,FT4水平[(18.35±6.19),(76.28±23.49)pmol/L]明显高于对照组[(4.75±0.31),(16.12±3.27)pmol/L],sTSH水平[(0.15±0.07)mU/L]明显低于对照组[(3.78±0.15)mU/L],差异均有统计学意义(P＜0.01),甲低组FT3,FT4水平[(3.36±0.26),(6.37±2.19)pmol/L]均低于对照组(P＜0.05),sTSH[(44.58±13.29)mU/L]明显高于对照组(P＜0.01),亚甲低组FT3,FT4水平[(4.86±0.45),(15.26±2.78)pmol/L]与对照组比较,差异无统计学意义(P＞0.05),sTSH[(14.26±4.73)mU/L]明显高丁对照组(P＜0.01).甲亢组血清PCⅢ水平[(4.63±1.22)μg/L]明显高于甲低组[(3.64±1.12)μg/L],亚甲低组[(3.54±1.17)μg/L],对照组[(3.56±1.07)μg/L],组问两两比较差异有统计学意义(P＜0.05),而甲低组,哑甲低组,对照组PCⅢ水平任意两组间比较,差异均无统计学意义(P＞0.05),甲低组血清HA水平[(31.13±10.28)μg/L]高于甲亢组[(22.24±7.22)μg/L],亚甲低组[(22.43 4-7.99)μg/L]和对照组[(23.09±9.19)μg/L],组间两两比较差异均有统计学意义(P＜0.05),而甲低组,亚甲低组,对照组HA水平任意两组比较,差异均无统计学意义(P＞0.05).结论 在排除肝纤维化等病变的情况下,检测甲亢患者血清PCⅢ,对了解早期的心肌纤维化有重要意义,对病程较长的甲亢患者,血清HA,PCⅢ的榆测可作为早期发现肝损伤和纤维化的参考依据.
目的 觀察自身免疫性甲狀腺疾病(AITD)患者血清Ⅲ型前膠原(PCⅢ)和透明質痠(HA)水平.探討其臨床意義.方法 按甲狀腺功能將114例AITD患者分為3組:①Graves病甲狀腺功能亢進(簡稱甲亢)組(38例),②橋本甲狀腺炎甲狀腺功能低下(簡稱甲低)組(35例),③橋本甲狀腺炎亞臨床甲狀腺功能低下(簡稱啞甲低)組(41例),另設40例健康人作為對照組.用免疫化學髮光法檢測以上各組人群血清遊離三碘甲腺原氨痠(FT3),遊離甲狀腺素(FT4),超敏促甲狀腺激素(sTSH)水平.用酶聯免疫吸附試驗(ELISA)檢測血清PCⅢ水平,用放射免疫分析法(RIA)檢測血清HA水平.結果 甲亢組血清FT3,FT4水平[(18.35±6.19),(76.28±23.49)pmol/L]明顯高于對照組[(4.75±0.31),(16.12±3.27)pmol/L],sTSH水平[(0.15±0.07)mU/L]明顯低于對照組[(3.78±0.15)mU/L],差異均有統計學意義(P＜0.01),甲低組FT3,FT4水平[(3.36±0.26),(6.37±2.19)pmol/L]均低于對照組(P＜0.05),sTSH[(44.58±13.29)mU/L]明顯高于對照組(P＜0.01),亞甲低組FT3,FT4水平[(4.86±0.45),(15.26±2.78)pmol/L]與對照組比較,差異無統計學意義(P＞0.05),sTSH[(14.26±4.73)mU/L]明顯高丁對照組(P＜0.01).甲亢組血清PCⅢ水平[(4.63±1.22)μg/L]明顯高于甲低組[(3.64±1.12)μg/L],亞甲低組[(3.54±1.17)μg/L],對照組[(3.56±1.07)μg/L],組問兩兩比較差異有統計學意義(P＜0.05),而甲低組,啞甲低組,對照組PCⅢ水平任意兩組間比較,差異均無統計學意義(P＞0.05),甲低組血清HA水平[(31.13±10.28)μg/L]高于甲亢組[(22.24±7.22)μg/L],亞甲低組[(22.43 4-7.99)μg/L]和對照組[(23.09±9.19)μg/L],組間兩兩比較差異均有統計學意義(P＜0.05),而甲低組,亞甲低組,對照組HA水平任意兩組比較,差異均無統計學意義(P＞0.05).結論 在排除肝纖維化等病變的情況下,檢測甲亢患者血清PCⅢ,對瞭解早期的心肌纖維化有重要意義,對病程較長的甲亢患者,血清HA,PCⅢ的榆測可作為早期髮現肝損傷和纖維化的參攷依據.
목적 관찰자신면역성갑상선질병(AITD)환자혈청Ⅲ형전효원(PCⅢ)화투명질산(HA)수평.탐토기림상의의.방법 안갑상선공능장114례AITD환자분위3조:①Graves병갑상선공능항진(간칭갑항)조(38례),②교본갑상선염갑상선공능저하(간칭갑저)조(35례),③교본갑상선염아림상갑상선공능저하(간칭아갑저)조(41례),령설40례건강인작위대조조.용면역화학발광법검측이상각조인군혈청유리삼전갑선원안산(FT3),유리갑상선소(FT4),초민촉갑상선격소(sTSH)수평.용매련면역흡부시험(ELISA)검측혈청PCⅢ수평,용방사면역분석법(RIA)검측혈청HA수평.결과 갑항조혈청FT3,FT4수평[(18.35±6.19),(76.28±23.49)pmol/L]명현고우대조조[(4.75±0.31),(16.12±3.27)pmol/L],sTSH수평[(0.15±0.07)mU/L]명현저우대조조[(3.78±0.15)mU/L],차이균유통계학의의(P＜0.01),갑저조FT3,FT4수평[(3.36±0.26),(6.37±2.19)pmol/L]균저우대조조(P＜0.05),sTSH[(44.58±13.29)mU/L]명현고우대조조(P＜0.01),아갑저조FT3,FT4수평[(4.86±0.45),(15.26±2.78)pmol/L]여대조조비교,차이무통계학의의(P＞0.05),sTSH[(14.26±4.73)mU/L]명현고정대조조(P＜0.01).갑항조혈청PCⅢ수평[(4.63±1.22)μg/L]명현고우갑저조[(3.64±1.12)μg/L],아갑저조[(3.54±1.17)μg/L],대조조[(3.56±1.07)μg/L],조문량량비교차이유통계학의의(P＜0.05),이갑저조,아갑저조,대조조PCⅢ수평임의량조간비교,차이균무통계학의의(P＞0.05),갑저조혈청HA수평[(31.13±10.28)μg/L]고우갑항조[(22.24±7.22)μg/L],아갑저조[(22.43 4-7.99)μg/L]화대조조[(23.09±9.19)μg/L],조간량량비교차이균유통계학의의(P＜0.05),이갑저조,아갑저조,대조조HA수평임의량조비교,차이균무통계학의의(P＞0.05).결론 재배제간섬유화등병변적정황하,검측갑항환자혈청PCⅢ,대료해조기적심기섬유화유중요의의,대병정교장적갑항환자,혈청HA,PCⅢ적유측가작위조기발현간손상화섬유화적삼고의거.
Obecfive To study the clinical significance of detecting serum proeollagen type Ⅲ(PCⅢ) and hyaluronie acid(HA)in patients with autoimmune thyroid diseases(AITD).Methods According to the thyroid function,the 114 patients with AITD were divided into hyperthyroidism group(38),hypothyroidism group(35),and sub-hypothyroidism group(41).In addition,40 healthy persons were served as controls.The level of serum PCⅢ was determined with ELISA and that of serum HA with RIA.The level of FT3,FT4 and sTSH were detected by immumnofluorometric assay.Results Serum FT3(18.35±6.19)pmol/L]and FT4[(76.28±23.49)pmol/L]level of patients with hyperthyroidism were obviously higher than those of the controls[(4.75±0.31),(16.12±3.27) pmol/L],but serum sTSH[(0.15±0.07)mU/L]was obviously lower than that of the control[(3.78±0.15)mU/L],the differences were statically significant(P＜0.01).Serum FT3[(3.36±0.26)pmol/L]and FT4 [(6.37±2.19) pmol/L]level of patients with hypothyroidism were both lower than those of the controls(P＜0.05).but serum sTSH[(44.58±13.29)mU/L]was obviously higher than that of the control(P＜0.01).Serum FT3 [(4.86±0.45)pmol/L]and FT4[(15.26±2.78)pmol/L]level of patients with sub-hypothyroidism had no statistical difference compared with those of the controls(P＞0.05),but serum sTSH[(14.26±4.73)mU/L] was obviously higher than that of the controls(P＜0.01).The level of sernm PCⅢ[(4.63±1.22)μg/L]in pafients with hyperthyroidism was significantly higher than that of any other group(P＜0.05).There waB no statistical significant difference in PCⅢ among the patients with hypothyroidism,the patients with sub-hypothyroidism and controls [(3.64±1.12),(3.54±1.17)and(3.56±1.07)μg/L],respectively(P＞0.05).The level of serum HA [(31.13±10.28)μg/L]in patients with hypothyroidism was significantly higher than that of any other group(P＜0.05).There was no statistical significant difference in HA among the patients with hyperthyroidism,the patients with sub-hypothyroidism and controls[(22.24±7.22),(22.43±7.99)and(23.09±9.19)μg/L,respectively,P＞0.05].Conclusions It is very significant to understand myocardial fibrosis early through detecting sernm PCⅢ in patients with hyperthyroidism.Measurement of serum PCⅢ and HA will be useful to discovery hepatic fibrosisearly in patients with a long course of hyperthyroidism.
