中华肝胆外科杂志
中華肝膽外科雜誌
중화간담외과잡지
CHINESE JOURNAL OF HEPATOBILIARY SURGERY
2012年
1期
23-26
,共4页
夏红天%郭广宏%黄晓强%王敬
夏紅天%郭廣宏%黃曉彊%王敬
하홍천%곽엄굉%황효강%왕경
肝细胞肝癌%手术切除%肝动脉栓塞化疗%细胞因子%血管内皮细胞
肝細胞肝癌%手術切除%肝動脈栓塞化療%細胞因子%血管內皮細胞
간세포간암%수술절제%간동맥전새화료%세포인자%혈관내피세포
Hepatocellular carcinoma%Surgical resection%Transcatheter arterial chemoembolization%Cytokines%Vascular endothelial cells
目的 与手术切除比较,明确肝细胞癌肝动脉栓塞化疗(TACE)前、后血管内皮细胞生长相关细胞因子含量变化.方法 手术切除组30例,TACE组30例.利用生物蛋白芯片技术检测血清中多种细胞因子的含量.结果 治疗前两组患者血管内皮相关细胞因子含量无显著差异.治疗后两组患者血清促血管内皮细胞生长因子显著下降,抑制血管内皮细胞生长因子显著升高.肝细胞癌患者行TACE治疗后血清中细胞因子IL-6、IL-8、VEGF和EGF的含量(分别为94.57±20.23、52.17±7.78、165.05±28.65、53.49±9.73 pg/ml)明显高于手术切除组(分别为67.27±20.08、23.48±9.16、128.37±43.43、70.96±13.88 pg/ml),P＜0.01；而细胞因子IL-10、IFNγ和TNFα的含量(分别为0.82±0.31、1.02±0.22、8.80±2.87 pg/ml)明显低于手术切除组(分别为1.09±0.29、1.57±0.31、6.97±1.54 pg/ml),P＜0.01.结论 TACE治疗后患者血清促进血管内皮细胞生长的细胞因子含量明显高于手术切除组；而抑制血管内皮细胞生长的细胞因子含量明显低于手术切除组.肝细胞癌根治性手术切除对肿瘤血管内皮细胞生成因子的抑制作用明显好于TACE治疗的抑制作用.
目的 與手術切除比較,明確肝細胞癌肝動脈栓塞化療(TACE)前、後血管內皮細胞生長相關細胞因子含量變化.方法 手術切除組30例,TACE組30例.利用生物蛋白芯片技術檢測血清中多種細胞因子的含量.結果 治療前兩組患者血管內皮相關細胞因子含量無顯著差異.治療後兩組患者血清促血管內皮細胞生長因子顯著下降,抑製血管內皮細胞生長因子顯著升高.肝細胞癌患者行TACE治療後血清中細胞因子IL-6、IL-8、VEGF和EGF的含量(分彆為94.57±20.23、52.17±7.78、165.05±28.65、53.49±9.73 pg/ml)明顯高于手術切除組(分彆為67.27±20.08、23.48±9.16、128.37±43.43、70.96±13.88 pg/ml),P＜0.01；而細胞因子IL-10、IFNγ和TNFα的含量(分彆為0.82±0.31、1.02±0.22、8.80±2.87 pg/ml)明顯低于手術切除組(分彆為1.09±0.29、1.57±0.31、6.97±1.54 pg/ml),P＜0.01.結論 TACE治療後患者血清促進血管內皮細胞生長的細胞因子含量明顯高于手術切除組；而抑製血管內皮細胞生長的細胞因子含量明顯低于手術切除組.肝細胞癌根治性手術切除對腫瘤血管內皮細胞生成因子的抑製作用明顯好于TACE治療的抑製作用.
목적 여수술절제비교,명학간세포암간동맥전새화료(TACE)전、후혈관내피세포생장상관세포인자함량변화.방법 수술절제조30례,TACE조30례.이용생물단백심편기술검측혈청중다충세포인자적함량.결과 치료전량조환자혈관내피상관세포인자함량무현저차이.치료후량조환자혈청촉혈관내피세포생장인자현저하강,억제혈관내피세포생장인자현저승고.간세포암환자행TACE치료후혈청중세포인자IL-6、IL-8、VEGF화EGF적함량(분별위94.57±20.23、52.17±7.78、165.05±28.65、53.49±9.73 pg/ml)명현고우수술절제조(분별위67.27±20.08、23.48±9.16、128.37±43.43、70.96±13.88 pg/ml),P＜0.01；이세포인자IL-10、IFNγ화TNFα적함량(분별위0.82±0.31、1.02±0.22、8.80±2.87 pg/ml)명현저우수술절제조(분별위1.09±0.29、1.57±0.31、6.97±1.54 pg/ml),P＜0.01.결론 TACE치료후환자혈청촉진혈관내피세포생장적세포인자함량명현고우수술절제조；이억제혈관내피세포생장적세포인자함량명현저우수술절제조.간세포암근치성수술절제대종류혈관내피세포생성인자적억제작용명현호우TACE치료적억제작용.
Objective To determine the serum levels of cytokines associated with vascular endothelial cells before and after treatment with either transcatheter arterial chemoembolization (TACE) or partial hepatectomy in patients with hepatocellular carcinoma (HCC).Methods There were 30 patients who received partial hepatectomy (the operation group) and 30 patients who received TACE (the TACE group).Cytokines were measured before and after treatment.Results The serum levels of IL-1β,IL-6,IL-8,VEGF and EGF of the post-TACE patients were significantly lower than the pre-TACE patients.The serum levels of IL-10,IFNγ and TNFα of the post-TACE patients were significantly higher than the pre-TACE patients.The serum levels of IL-1β,IL-6.IL-8,VEGF and EGF in the postoperative patients were significantly lower than the post-TACE patients.The serum levels of IL-10,IFNγ and TNFα of the postoperative patients were significantly higher than the post-TACE patients.Conclusion The results suggested that the serum levels of angiogenic factors in the postTACE patients were significantly higher than the postoperative patients.The serum levels of the inhibitors of vascular endothelial cells of the post-TACE patients were significantly lower than the postoperative patients.
