CAJ | 학술논문

目的了解慢性主观性耳鸣患者耳鸣频率对药物治疗效果及预后的影响.方法对2011年10月至2012年3月就诊的72例(93耳)慢性主观性耳鸣患者进行研究,根据耳鸣匹配检查分为低频组(23耳)、中频组(14耳)和高频组(56耳),所有病例均采用改善微循环+激素治疗(5％葡萄糖250 ml+银杏叶提取物87.5 mg+地塞米松10 mg静脉滴注),3周后评定疗效并对影响预后因素进行相关分析.结果耳鸣患者经药物治疗后痊愈0耳(0％)、显效0耳(0％)、有效18耳(19.4％)、无效75耳(80.6％).其中低频、中频及高频组的有效率分别为39.1％( 9/23)、35.7％(5/14)和7.1％(4/56),高频耳鸣的药物疗效明显差于低频和中频耳鸣,差异有统计学意义(x2=9.919,P=0.002;x2=5.809,P=0.016);低频耳鸣和中频耳鸣之间的有效率差异无统计学意义(P=0.559).耳鸣频率的差异对药物治疗的预后有影响(Logistic回归分析,P=0.001).结论慢性主观性耳鸣患者激素及改善微循环治疗效果欠佳,其中低中频耳鸣的疗效要好于高频耳鸣,耳鸣频率的差异可能是影响其药物疗效及预后的主要因素.
목적 료해만성주관성이명환자이명빈솔대약물치료효과급예후적영향.방법 대2011년10월지2012년3월취진적72례(93이)만성주관성이명환자진행연구,근거이명필배검사분위저빈조(23이)、중빈조(14이)화고빈조(56이),소유병례균채용개선미순배+격소치료(5％포도당250 ml+은행협제취물87.5 mg+지새미송10 mg정맥적주),3주후평정료효병대영향예후인소진행상관분석.결과 이명환자경약물치료후전유0이(0％)、현효0이(0％)、유효18이(19.4％)、무효75이(80.6％).기중저빈、중빈급고빈조적유효솔분별위39.1％( 9/23)、35.7％(5/14)화7.1％(4/56),고빈이명적약물료효명현차우저빈화중빈이명,차이유통계학의의(x2=9.919,P=0.002;x2=5.809,P=0.016);저빈이명화중빈이명지간적유효솔차이무통계학의의(P=0.559).이명빈솔적차이대약물치료적예후유영향(Logistic회귀분석,P=0.001).결론 만성주관성이명환자격소급개선미순배치료효과흠가,기중저중빈이명적료효요호우고빈이명,이명빈솔적차이가능시영향기약물료효급예후적주요인소.
Objective To investigate the influence of tinnitus frequency on medication and prognosis in patients with chronic subjective tinnitus.Methods Seventy-two patients (Ninety-three ears) diagnosed as chronic subjective tinnitus were studied from October 2010 to March 2011.All cases were divided into low frequency (twenty-three ears ),medium frequency (fourteen ears ) and high frequency (fifty-six ears) according to tinnitus matching test.All cases were treated with microcirculation promotion and steroid therapy (5％ glucose 250 ml + ginkgo biloba extract 87.5 mg + dexamethasone 10 mg intravenous drip).Curative effect was evaluated and the factors of prognosis were analyzed after three weeks.Results After medication,results were acquired as follows:recovery in 0 ear ( 0％ ),excellent in 0 ear (0％),effective in 18 ears( 19.4％ ),invalid in 75 ear(80.6％ ).The effective percentage was 39.1％,35.7％ and 7.1％,respectively.There was significant difference between these groups,but no significant difference between low frequency and medium frequency.Logistic regression analysis showed that the difference of frequency was significant prognostic factors for medication.Conclusions Microcirculation promotion and steroid therapy had a poor treatment effect in patients with chronic subjective tinnitus.The prognosis of chronic low-medium frequency tinnitus was better than chronic high frequency tinnitus.The difference of frequency retained significant influence on effects and prognosis of medication.