中华皮肤科杂志
中華皮膚科雜誌
중화피부과잡지
Chinese Journal of Dermatology
2008年
12期
790-792
,共3页
殷文浩%丁韧烨%盛桂芳%吴贤杰%陈怿%谭宇辉%郑敏
慇文浩%丁韌燁%盛桂芳%吳賢傑%陳懌%譚宇輝%鄭敏
은문호%정인엽%성계방%오현걸%진역%담우휘%정민
银屑病%趋化因子,CC%CCL27
銀屑病%趨化因子,CC%CCL27
은설병%추화인자,CC%CCL27
Psoriasis%Chemokines,CC%CCL27
目的 检测寻常性银屑病患者血清CCL27水平并探讨其临床意义.方法 采用酶联免疫吸附法检测61例寻常性银屑病患者治疗前后和45例健康人血清CCL27水平.结果 61例寻常性银屑病患者血清CCL27水平为(670.02±262.15)ng/L,健康人对照组为(373.10±92.84)ng/L,两组差异有统计学意义(t=8.18,P＜0.01).进行期患者血清CCL27水平为(799.94±214.54)ng/L,静止期为(422.57 ±135.53)ng/L,两组差异有统计学意义(t=8.39,P＜0.01).经药物治疗8周后,银屑病患者PASI评分下降70%以上者36例,其CCL27水平明显下降,与治疗前比较,差异有统计学意义(t=9.95,P＜0.01);PASI评分下降不足70%者25例,CCL27水平与治疗前比较差异无统计学意义(t=1.84,P＞0.05).61例银屑病患者血清CCL27水平与PASI评分呈正相关(r=0.58,P＜0.01).结论 寻常性银屑病患者血清CCL27水平明显增高,并与疾病活动性相关.
目的 檢測尋常性銀屑病患者血清CCL27水平併探討其臨床意義.方法 採用酶聯免疫吸附法檢測61例尋常性銀屑病患者治療前後和45例健康人血清CCL27水平.結果 61例尋常性銀屑病患者血清CCL27水平為(670.02±262.15)ng/L,健康人對照組為(373.10±92.84)ng/L,兩組差異有統計學意義(t=8.18,P＜0.01).進行期患者血清CCL27水平為(799.94±214.54)ng/L,靜止期為(422.57 ±135.53)ng/L,兩組差異有統計學意義(t=8.39,P＜0.01).經藥物治療8週後,銀屑病患者PASI評分下降70%以上者36例,其CCL27水平明顯下降,與治療前比較,差異有統計學意義(t=9.95,P＜0.01);PASI評分下降不足70%者25例,CCL27水平與治療前比較差異無統計學意義(t=1.84,P＞0.05).61例銀屑病患者血清CCL27水平與PASI評分呈正相關(r=0.58,P＜0.01).結論 尋常性銀屑病患者血清CCL27水平明顯增高,併與疾病活動性相關.
목적 검측심상성은설병환자혈청CCL27수평병탐토기림상의의.방법 채용매련면역흡부법검측61례심상성은설병환자치료전후화45례건강인혈청CCL27수평.결과 61례심상성은설병환자혈청CCL27수평위(670.02±262.15)ng/L,건강인대조조위(373.10±92.84)ng/L,량조차이유통계학의의(t=8.18,P＜0.01).진행기환자혈청CCL27수평위(799.94±214.54)ng/L,정지기위(422.57 ±135.53)ng/L,량조차이유통계학의의(t=8.39,P＜0.01).경약물치료8주후,은설병환자PASI평분하강70%이상자36례,기CCL27수평명현하강,여치료전비교,차이유통계학의의(t=9.95,P＜0.01);PASI평분하강불족70%자25례,CCL27수평여치료전비교차이무통계학의의(t=1.84,P＞0.05).61례은설병환자혈청CCL27수평여PASI평분정정상관(r=0.58,P＜0.01).결론 심상성은설병환자혈청CCL27수평명현증고,병여질병활동성상관.
Objective To determine the serum level of chernokine CCL27 in patients with psoriasis vulgaris,and to analyse its clinical relevance.Methods A total of 61 patients(40 in progressive stage and 21 in stable stage)with psoriasis vulgaris,with an average disease duration of 37.97±14.34 years,were included in this study.Appropriate thempy was given to these patients.Serum samples were collected from the patients before and after therapy,as well as from 45 healthy human controls.ELISA was applied to examine the serum concentration of CCL27.Clinical severity of psoriasis vulgaris was assessed by psoriasis area and severity index(PASI)score.Results Serum level of CCL27 was 670.02±262.15 ng/L in psoriatic patients,compared to 373.10±92.84 ng/L in the controls(t=8.18.P＜0.01).Increased serum level of CCL27 was observed in patients with progressive psoriasis vulgaris compared to those with stable psoriasis (799.94±214.54 ng/L vs 422.57±135.53 ng/L,t=8.39,P＜0.01).After 8 weeks of therapy,a significant decrease was noticed in the serum level of CCL27 in patients who experienced≥70%reduction in PASI score(t=9.95,P＜0.01).but not in those experiencing a PASI reduction of＜70%(t=1.84,P＞0.05).The serum level of CCL27 was positively correlated with PASI score(r=0.58,P＜0.01).Conclusions The serum level of CCL27 is significantly elevated in patients with psoriasis vulgaris,and it is correlated with the disease severity.
