中华生物医学工程杂志
中華生物醫學工程雜誌
중화생물의학공정잡지
CHINESE JOURNAL OF BIOMEDICAL ENGINEERING
2010年
3期
263-267
,共5页
张一秋%石洪成%顾宇参%刘文官%修雁%李蓓蕾%朱玮珉%陈曙光
張一鞦%石洪成%顧宇參%劉文官%脩雁%李蓓蕾%硃瑋珉%陳曙光
장일추%석홍성%고우삼%류문관%수안%리배뢰%주위민%진서광
放射性核素显像%体层摄影术,发射型计算机,单光子%腺苷%局部血流%脑
放射性覈素顯像%體層攝影術,髮射型計算機,單光子%腺苷%跼部血流%腦
방사성핵소현상%체층섭영술,발사형계산궤,단광자%선감%국부혈류%뇌
Radionuclide imaging%Tomography,emission-computed,single-photon%Adenosine%Regional blood flow%Brain
目的 数为参照,分别计算两侧大脑额叶、颞叶、顶叶、枕叶ROI放射性计数与其比值,比较同一组ROI在腺苷负荷状态下与静息状态下放射性计数比值.对视为异常部位的大脑ROI按其对腺苷负荷后脑血流灌注变化的反应进行分类.结果 所有患者进行腺苷负荷显像,没有因出现严重不良反应而终止,部分患者出现轻微不良反应并在腺苷注射结束后迅速消失.共获得视为正常的174组大脑ROI,静息显像的比值与负荷显像的比值比较显示,额叶、颞叶、顶叶差异有统计学意义(0.901±0.100比0.956±0.149,0.923±0.070比0.981±0.090,0.840±0.126比0.887±0.091,均P<0.05),枕叶差异无统计学意义(1.102±0.146比1.010±0.124,P>0.05).获得视为异常的49处ROI,其中静息状态局部脑血流量正常,腺苷负荷后局部脑血流量减低的有10处;静息状态局部脑血流量减低,腺苷负荷后局部脑血流量减低更加明显的有9处;静息状态局部脑血流量减低,腺苷负荷后局部脑血流量减低改善的有27处;静息状态局部脑血流量减低,腺苷负荷后局部脑血流量减低区无明显变化的有3处.结论 腺苷能用于负荷脑血流灌注显像,且不良反应少.
目的 數為參照,分彆計算兩側大腦額葉、顳葉、頂葉、枕葉ROI放射性計數與其比值,比較同一組ROI在腺苷負荷狀態下與靜息狀態下放射性計數比值.對視為異常部位的大腦ROI按其對腺苷負荷後腦血流灌註變化的反應進行分類.結果 所有患者進行腺苷負荷顯像,沒有因齣現嚴重不良反應而終止,部分患者齣現輕微不良反應併在腺苷註射結束後迅速消失.共穫得視為正常的174組大腦ROI,靜息顯像的比值與負荷顯像的比值比較顯示,額葉、顳葉、頂葉差異有統計學意義(0.901±0.100比0.956±0.149,0.923±0.070比0.981±0.090,0.840±0.126比0.887±0.091,均P<0.05),枕葉差異無統計學意義(1.102±0.146比1.010±0.124,P>0.05).穫得視為異常的49處ROI,其中靜息狀態跼部腦血流量正常,腺苷負荷後跼部腦血流量減低的有10處;靜息狀態跼部腦血流量減低,腺苷負荷後跼部腦血流量減低更加明顯的有9處;靜息狀態跼部腦血流量減低,腺苷負荷後跼部腦血流量減低改善的有27處;靜息狀態跼部腦血流量減低,腺苷負荷後跼部腦血流量減低區無明顯變化的有3處.結論 腺苷能用于負荷腦血流灌註顯像,且不良反應少.
목적 수위삼조,분별계산량측대뇌액협、섭협、정협、침협ROI방사성계수여기비치,비교동일조ROI재선감부하상태하여정식상태하방사성계수비치.대시위이상부위적대뇌ROI안기대선감부하후뇌혈류관주변화적반응진행분류.결과 소유환자진행선감부하현상,몰유인출현엄중불량반응이종지,부분환자출현경미불량반응병재선감주사결속후신속소실.공획득시위정상적174조대뇌ROI,정식현상적비치여부하현상적비치비교현시,액협、섭협、정협차이유통계학의의(0.901±0.100비0.956±0.149,0.923±0.070비0.981±0.090,0.840±0.126비0.887±0.091,균P<0.05),침협차이무통계학의의(1.102±0.146비1.010±0.124,P>0.05).획득시위이상적49처ROI,기중정식상태국부뇌혈류량정상,선감부하후국부뇌혈류량감저적유10처;정식상태국부뇌혈류량감저,선감부하후국부뇌혈류량감저경가명현적유9처;정식상태국부뇌혈류량감저,선감부하후국부뇌혈류량감저개선적유27처;정식상태국부뇌혈류량감저,선감부하후국부뇌혈류량감저구무명현변화적유3처.결론 선감능용우부하뇌혈류관주현상,차불량반응소.
Objective To explore the feasibility of adenosine in stress brain blood flow perfusion imaging. Methods Between April 2008 and May 2009, thirty-two patients with non-organic mental disorders registered to our department underwent rest and adenosine stress brain blood flow perfusion imaging using two days protocol. Three reference slices in the reconstructive transverse image were selected to draw regions of interest (ROI) in bilateral symmetrical cerebellums, frontal lobes, temporal lobes, parietal lobes and occipital lobes in the normal cerebrum lobes.The size of ROI was 32.8 pixels.The radioactive counts of each ROI were calculated. Using the mean radioactive counts of bilateral cerebellum ROI as a reference,the ratio of radioactive counts of each cerebrum ROI over mean radioactive counts of bilateral cerebellum ROI was calculated. The ratio of radioactive counts of each cerebrum ROI underwent adenosine stress or rest in the same group was compared. The response to adenosine stress of cerebrums ROI in the abnormal cerebrum lobes were analyzed, which was classified by the change of the cerebral blood flow perfusion. Results All the patients underwent adenosine stress brain blood flow imaging and none withdrew due to severe adverse effects. Mild systemic adverse reactions did occur in some patients but disappeared quickly after adenosine injection. Among the 174 normal cerebrum ROI acquired, the ratio of radioactive counts of cerebrum ROI underwent rest or adenosine stress showed statistical significance in the frontal lobe (0.901±0.100 vs 0.956±0.149, P<0.05), temporal lobe (0.923±0.070 vs 0.981±0.090, P<0.05) and parietal lobe (0.840±0.126 vs 0.887±0.091, P<0.05), but not in the occipital lobe (1.102±0.146 vs 1.010±0.124, P>0.05). Of the 49 abnormal cerebrum ROI, ten showed normal regional cerebral blood flow at rest which was lowered during adenosine stress, nine had low regional cerebral blood flow at rest which was even worse during adenosine stress, twenty-seven had low regional cerebral blood flow at rest which appeared improved during adenosine stress, and three showed low regional cerebral blood flow that was comparable at rest and during adenosine stress. Conclusion Adenosine may be used for stress brain blood flow perfusion imaging with low incidence of adverse effects.