CAJ | 학술논문

目的探索血浆血管内皮生长因子(VEGF)在子宫内膜癌中的表达.方法收集新疆地区50例维吾尔族子宫内膜样腺癌患者血浆,收集40例健康维吾尔族妇女血浆为正常对照.用酶联免疫法测血浆VEGF含量,分析子宫内膜癌同血管内皮生长因子的相关性.分析子宫内膜癌各临床分期及分化程度血浆VEGF的变化状况.结果子宫内膜样腺癌血浆VEGF水平同正常对照血浆相比差异有统计学意义(P＜0.01);晚期(Ⅲ期、Ⅳ期)子宫内膜样腺癌血浆VEGF增高的水平与早期(Ⅰ期、Ⅱ期)子宫内膜样腺癌相比差异有统计学意义(P＜0.01),在不同分化程度的子宫内膜样腺癌中,随着分化程度的加重,血浆VEGF水平增高,各组相比差异有统计学意义(P＜0.05).结论子宫内膜癌与血浆VEGF水平增高相关,血浆VEGF水平与临床分期、分化程度相关,临床分期晚的和分化程度低的血浆VEGF水平增高更加明显.
목적 탐색혈장혈관내피생장인자(VEGF)재자궁내막암중적표체.방법 수집신강지구50례유오이족자궁내막양선암환자혈장,수집40례건강유오이족부녀혈장위정상대조.용매련면역법측혈장VEGF함량,분석자궁내막암동혈관내피생장인자적상관성.분석자궁내막암각림상분기급분화정도혈장VEGF적변화상황.결과 자궁내막양선암혈장VEGF수평동정상대조혈장상비차이유통계학의의(P＜0.01);만기(Ⅲ기、Ⅳ기)자궁내막양선암혈장VEGF증고적수평여조기(Ⅰ기、Ⅱ기)자궁내막양선암상비차이유통계학의의(P＜0.01),재불동분화정도적자궁내막양선암중,수착분화정도적가중,혈장VEGF수평증고,각조상비차이유통계학의의(P＜0.05).결론 자궁내막암여혈장VEGF수평증고상관,혈장VEGF수평여림상분기、분화정도상관,림상분기만적화분화정도저적혈장VEGF수평증고경가명현.
Objective To explore the relationships of serum vascular endothelial growth factor (VEGF) and endometrial cancer of Uighur Women in Xinjiang.Methods The serum of 50 endometrial cancer patient's and 70 healthy women's were collected.VEGF expressions were tested by ELISA method and the correlations of endometrial cancer with VEGF were analysed.The variety of serum VEGF in different clinical stages of endometriat cancer was analyzed.Results Serum VEGF expressions on endometrial cancer were significantly higher than normal ones (P＜0.01);The serum VEGF level in late stage was significantly higher than early stage (P＜0.01).The serum VEGF level significantly increased from well differentiated to the poorly differentiated cases (P＜0.05).Conclusion high level expressions of VEGF are related to the endometrial cancer.Uighur Women in Xinjiang,particularly high expressed in advanced and poorly differentiated endometrial cancer.