国际呼吸杂志
國際呼吸雜誌
국제호흡잡지
INTERNATIONAL JOURNAL OF RESPIRATION
2008年
6期
329-331
,共3页
碱性成纤维细胞因子%肺纤维化
堿性成纖維細胞因子%肺纖維化
감성성섬유세포인자%폐섬유화
Basic fibroblast growth factor%Pulmonary fibrosis
碱性成纤维细胞生长因子(basic fibroblast growth factor,bFGF)是一种重要的多肽生长因子,也是成纤维细胞因子(fibroblast growth factor,FGF)家族原型成员之一.随着对细胞因子在特发性肺纤维化(idiopathic pulmonary fibrosis,IPF)发病中作用认识的逐渐深入,近年研究发现bFGF在纤维化的肺组织、血清、肺泡灌洗液中有高表达并与肺纤维化程度呈正相关,这提示bFGF表达上调与肺纤维化关系密切,抑制促纤维化的细胞因子为IPF的治疗提供了一条新的有效途径[1].
堿性成纖維細胞生長因子(basic fibroblast growth factor,bFGF)是一種重要的多肽生長因子,也是成纖維細胞因子(fibroblast growth factor,FGF)傢族原型成員之一.隨著對細胞因子在特髮性肺纖維化(idiopathic pulmonary fibrosis,IPF)髮病中作用認識的逐漸深入,近年研究髮現bFGF在纖維化的肺組織、血清、肺泡灌洗液中有高錶達併與肺纖維化程度呈正相關,這提示bFGF錶達上調與肺纖維化關繫密切,抑製促纖維化的細胞因子為IPF的治療提供瞭一條新的有效途徑[1].
감성성섬유세포생장인자(basic fibroblast growth factor,bFGF)시일충중요적다태생장인자,야시성섬유세포인자(fibroblast growth factor,FGF)가족원형성원지일.수착대세포인자재특발성폐섬유화(idiopathic pulmonary fibrosis,IPF)발병중작용인식적축점심입,근년연구발현bFGF재섬유화적폐조직、혈청、폐포관세액중유고표체병여폐섬유화정도정정상관,저제시bFGF표체상조여폐섬유화관계밀절,억제촉섬유화적세포인자위IPF적치료제공료일조신적유효도경[1].
Basic fibroblast growth factor(bFGF)is a significant polypeptide growth factor and one of prototype members in FGF family.With more knowledge about idiopathic pulmonary fibrosis(IPF),it has been discovered that bFGF is high expressed in the lung tissue,serum bronchoalveolar lavage fluid of fibrotic lung'and bFGF is positive correlated with the degree of pulmonary fibrosis.A new effective treatment in IPF can be developed by inhibiting those cytokines of promoting fibrosis.
