中国临床实用医学
中國臨床實用醫學
중국림상실용의학
CHINA CLINICAL PRACTICAL MEDICINE
2010年
9期
1-3
,共3页
上皮内瘤变%腺癌%存活素%细胞核增殖相关抗原
上皮內瘤變%腺癌%存活素%細胞覈增殖相關抗原
상피내류변%선암%존활소%세포핵증식상관항원
Intraepithelial neoplasia%Adenocarcinoma%Survivin%Ki-67
目的 研究存活素(Survivin)在结直肠腺瘤和腺癌中的表达及其临床意义.方法 应用免疫组织化学SABC法检测139例结直肠腺瘤及56例结直肠腺癌中Survivin及Ki-67的表达情况,分析二者与各临床病理指标之间的关系.结果 Survivin与Ki-67在结直肠腺瘤中的表达水平与性别、年龄及病理类型无关;而与腺瘤上皮内瘤变的级别有关.Survivin与Ki-67在结直肠腺癌中的表达水平与性别及年龄无关;而与Dukes分期、分化程度及淋巴结转移情况有关.Survivin与Ki-67在腺癌中的表达水平明显高于在腺瘤中的表达,差异具有统计学意义(x2值分别为30.014、23.142,P值均＜0.05).但是二者在高级别上皮内瘤变腺瘤组织与高分化腺癌组织中的表达水平之间的差异不具有统计学意义(x2值分别为0.129、0.007,P值分别为0.720、0.093＞0.05).在结直肠腺瘤及腺癌中Survivin与Ki-67的表达之间均具有正相关性.结论 联合检测Survivin及Ki-67有助于判断结直肠腺瘤及腺癌的恶性趋势及生物学行为,为结直肠腺瘤及腺癌的个体化治疗提供依据.
目的 研究存活素(Survivin)在結直腸腺瘤和腺癌中的錶達及其臨床意義.方法 應用免疫組織化學SABC法檢測139例結直腸腺瘤及56例結直腸腺癌中Survivin及Ki-67的錶達情況,分析二者與各臨床病理指標之間的關繫.結果 Survivin與Ki-67在結直腸腺瘤中的錶達水平與性彆、年齡及病理類型無關;而與腺瘤上皮內瘤變的級彆有關.Survivin與Ki-67在結直腸腺癌中的錶達水平與性彆及年齡無關;而與Dukes分期、分化程度及淋巴結轉移情況有關.Survivin與Ki-67在腺癌中的錶達水平明顯高于在腺瘤中的錶達,差異具有統計學意義(x2值分彆為30.014、23.142,P值均＜0.05).但是二者在高級彆上皮內瘤變腺瘤組織與高分化腺癌組織中的錶達水平之間的差異不具有統計學意義(x2值分彆為0.129、0.007,P值分彆為0.720、0.093＞0.05).在結直腸腺瘤及腺癌中Survivin與Ki-67的錶達之間均具有正相關性.結論 聯閤檢測Survivin及Ki-67有助于判斷結直腸腺瘤及腺癌的噁性趨勢及生物學行為,為結直腸腺瘤及腺癌的箇體化治療提供依據.
목적 연구존활소(Survivin)재결직장선류화선암중적표체급기림상의의.방법 응용면역조직화학SABC법검측139례결직장선류급56례결직장선암중Survivin급Ki-67적표체정황,분석이자여각림상병리지표지간적관계.결과 Survivin여Ki-67재결직장선류중적표체수평여성별、년령급병리류형무관;이여선류상피내류변적급별유관.Survivin여Ki-67재결직장선암중적표체수평여성별급년령무관;이여Dukes분기、분화정도급림파결전이정황유관.Survivin여Ki-67재선암중적표체수평명현고우재선류중적표체,차이구유통계학의의(x2치분별위30.014、23.142,P치균＜0.05).단시이자재고급별상피내류변선류조직여고분화선암조직중적표체수평지간적차이불구유통계학의의(x2치분별위0.129、0.007,P치분별위0.720、0.093＞0.05).재결직장선류급선암중Survivin여Ki-67적표체지간균구유정상관성.결론 연합검측Survivin급Ki-67유조우판단결직장선류급선암적악성추세급생물학행위,위결직장선류급선암적개체화치료제공의거.
Objective Investigate the expression of Survivin in colorectal adenoma and adenocarcinoma,and then analyze their correlation and their relationships with clinico-pathological features in order to explore the effect of Survivin in the transition from adenoma to adenocarcinoma.Methods Immunohistochemical(IHC) was used to detect the expressive levels of Survivin and Ki-67 in specimens collected from 139 patients with colorectal adenoma and 56 patients with colorectal adenocacinomal,to carry out statistic analysis compared with clinical features.Results There is correlation between Survivin,Ki-67's expressive levels in colorectal adenoma and the grade of intraepithelial neoplasia,but no correlation between their expressive levels and gender,age as well as pathological typing.There are correlations between Survivin,Ki-67 's expressive levels in colorectal adenocarcinoma and Dukes stage,pathological grading as well as lymphatic metastasis,but no correlation between their levels and gender as well as age.Both the Survivin and Ki-67 's expressive levels in adenocarcima are manifestly higher than in adenoma,the disparation has statistical significance (x2 = 30.014,23.142,P =0.000 ＜ 0.05 ).But there is no statistical significance of their exprssion in hige grade intraepithelial neoplasia adenoma and well-differentiated adenocarcinoma (x2 = 0.129,0.007 ,P = 0.720,0.093 ＞ 0.05 ).There are positive correlations between Survivin and Ki-67 in both adenoma and adenocarcinoma.Conclusion The evaluation and measurement of Survivin and Ki-67 might be used to judge the malignant tendency and biological behaviour,and can offer evidence to the individualized treatment for the patients with colorectal adenoma and adenocarcinoma.
