CAJ | 학술논문

目的探讨高尿酸血症与甲状腺功能异常的关系.方法调查10 405名21～89岁某石化企业员工人群,询问甲状腺疾病的手术、药物治疗史,检测血促甲状腺素(TSH)、游离甲状腺素(FT4)、游离三碘甲状腺原氨酸(FV3)和血尿酸(SUA).结果 ①该人群中高尿酸血症总患病率17.9%,男性22.6%,女性7.1%.②甲状腺疾病总体知晓率1.7%,男性0.9%,女性3.5%.③10 232名否认甲状腺疾病史者中,甲状腺功能异常总患病率4.2%,男性2.9%,其中TSH降低者0.4%,TSH升高者2.5%;女性7.2%,其中TSH降低者0.9%,TSH升高者6.3%.④与TSH正常组相比,不论性别,TSH升高组的血尿酸均显著升高(P<0.05),aSH降低组的血尿酸无显著变化.⑤TSH升高是高尿酸血症的独立影响因素(OR值男性为1.61、女性为1.72,P<0.01).结论高尿酸血症患病率与TSH升高显著相关,临床或亚临床甲状腺功能减退症可能是高尿酸血症的危险因素.
목적 탐토고뇨산혈증여갑상선공능이상적관계.방법 조사10 405명21～89세모석화기업원공인군,순문갑상선질병적수술、약물치료사,검측혈촉갑상선소(TSH)、유리갑상선소(FT4)、유리삼전갑상선원안산(FV3)화혈뇨산(SUA).결과 ①해인군중고뇨산혈증총환병솔17.9%,남성22.6%,녀성7.1%.②갑상선질병총체지효솔1.7%,남성0.9%,녀성3.5%.③10 232명부인갑상선질병사자중,갑상선공능이상총환병솔4.2%,남성2.9%,기중TSH강저자0.4%,TSH승고자2.5%;녀성7.2%,기중TSH강저자0.9%,TSH승고자6.3%.④여TSH정상조상비,불론성별,TSH승고조적혈뇨산균현저승고(P<0.05),aSH강저조적혈뇨산무현저변화.⑤TSH승고시고뇨산혈증적독립영향인소(OR치남성위1.61、녀성위1.72,P<0.01).결론 고뇨산혈증환병솔여TSH승고현저상관,림상혹아림상갑상선공능감퇴증가능시고뇨산혈증적위험인소.
Objective To study the relationship between the prevalence of hyperuricemia and thyroid dysfunction. Methods 10 405 active and retired workers aged 21 to 89 years in a Petrochemical Corporation in Ningho area of Zhejiang Province were included. Serum thyroid-stimulation hormone (TSH), free thyroxine thyroid diseases, the prevalence of thyroid dysfunction was 4.2%, 2.9% in male and 7.2% in female. The percentage of subjects with low TSH concentration was 0.4% in male and 0.9% in female,the percentage of TSH subjects,the serum uric acid was significantly increased in subjects with high TSH (P<0.05) and not an independent factor associated with hyperuricemia (OR=1.61 for male and 1.72 for female, P value was less than 0.01 for both). Conclusion The prevalence of hyperuricemia is significantly associated with increased TSH concentration. Overt or subclinical hypothyroidism may be risk factors for hyperuricemia.