CAJ | 학술논문

目的评估三维适形放疗(3DCRT)同步低剂量顺铂化疗治疗食管癌的疗效和不良反应.方法将89例不能手术或不愿手术的食管癌患者随机分为研究组(45例)和对照组(44例).研究组放射治疗同期每周接受1次顺铂30 mg化疗,连用5-6周;对照组行单纯放疗.两组采用3DCRT,总剂量60-65 Gy.结果研究组完全缓解(CR)28例,部分缓解(PR)11例,无变化(NC)6例;对照组CR18例,PR 12例,NC 11例,进展(PD)3例,两组差异有统计学意义(x2=5.476,P=0.019);研究组1、2、3年累积局部无复发率高于对照组,差异有统计学意义(x 2=3.87,P=0.0491);研究组1、2年生存率高于对照组,差异均有统计学意义(x2=4.602,P=0.032及x2=4.155,P=0.042).两组生存曲线差异有统计学意义(x2=6.44,P=0.0111).不良反应主要表现为放射性食管炎和白细胞减少,多为Ⅰ、Ⅱ度.结论低剂量顺铂化疗同步3DCRT治疗食管癌可显著提高患者的近期疗效、局部控制率和1、2年生存率,患者不良反应轻微.
목적 평고삼유괄형방료(3DCRT)동보저제량순박화료치료식관암적료효화불량반응.방법장89례불능수술혹불원수술적식관암환자수궤분위연구조(45례)화대조조(44례).연구조방사치료동기매주접수1차순박30 mg화료,련용5-6주;대조조행단순방료.량조채용3DCRT,총제량60-65 Gy.결과연구조완전완해(CR)28례,부분완해(PR)11례,무변화(NC)6례;대조조CR18례,PR 12례,NC 11례,진전(PD)3례,량조차이유통계학의의(x2=5.476,P=0.019);연구조1、2、3년루적국부무복발솔고우대조조,차이유통계학의의(x 2=3.87,P=0.0491);연구조1、2년생존솔고우대조조,차이균유통계학의의(x2=4.602,P=0.032급x2=4.155,P=0.042).량조생존곡선차이유통계학의의(x2=6.44,P=0.0111).불량반응주요표현위방사성식관염화백세포감소,다위Ⅰ、Ⅱ도.결론저제량순박화료동보3DCRT치료식관암가현저제고환자적근기료효、국부공제솔화1、2년생존솔,환자불량반응경미.
Objective To evaluate the therapeutic effectiveness and toxicity of low-dose cisplatin chemotherapy combined with three-dimensional conformal radiotherapy for mid-advanced esophageal cancer.Methods 89 patients with advanced esophageal cancer either who were inoperable or refused operation were randomized into two groups: 45 cases in the study group and 44 cases in the compared group. The study group