CAJ | 학술논문

目的探讨椎体骨髓脂肪含量(fat fraction,FF)在不同年龄组、性别的变化规律及与骨密度(bone mineral densities,BMD)的相关性.方法对85名年龄21～70岁健康志愿者及20名已行腰椎双能量X线吸收测定(dual X-ray absorptionmetry,DXA)诊断为骨质疏松的老年男女进行前瞻性MR波谱分析,测定L_3椎体脂肪分数值(fat fraction,FF).健康志愿者按每10岁为一个年龄段,将其分为5组,每组16～18人.结果 21～30岁组、31～40岁组、41～50岁组、51～60岁组、>60岁组和骨质疏松组的FF分别为30.7%±4.4%、35.5%±6.8%、41.9%士6.6%、46.8%±5.5%、51.7%±5.2%和59.2%±7.4%;除>60岁组和骨质疏松组外,各组L_3椎体脂肪含量男性均比女性高(P<0.05),其中,41～50岁组中的男女差别最大,达11.1%.骨质疏松组FF与BMD呈负相关关系(γ=-0.6,P<0.01).结论正常椎体骨髓脂肪含量随年龄而逐渐增加,~1H MRS可作为评价骨质量的新手段.
목적 탐토추체골수지방함량(fat fraction,FF)재불동년령조、성별적변화규률급여골밀도(bone mineral densities,BMD)적상관성.방법 대85명년령21～70세건강지원자급20명이행요추쌍능량X선흡수측정(dual X-ray absorptionmetry,DXA)진단위골질소송적노년남녀진행전첨성MR파보분석,측정L_3추체지방분수치(fat fraction,FF).건강지원자안매10세위일개년령단,장기분위5조,매조16～18인.결과 21～30세조、31～40세조、41～50세조、51～60세조、>60세조화골질소송조적FF분별위30.7%±4.4%、35.5%±6.8%、41.9%사6.6%、46.8%±5.5%、51.7%±5.2%화59.2%±7.4%;제>60세조화골질소송조외,각조L_3추체지방함량남성균비녀성고(P<0.05),기중,41～50세조중적남녀차별최대,체11.1%.골질소송조FF여BMD정부상관관계(γ=-0.6,P<0.01).결론 정상추체골수지방함량수년령이축점증가,~1H MRS가작위평개골질량적신수단.
Objective To study the changing of vertebral body marrow fat fraction(FF) in different age and sex and the relation-ship between FF and bone mineral densities (BMD). Methods Eighty-five healthy volunteers aged from 21 to 70 years old and twenty patients with osteoporosis based on T score after dual X-ray absorptionmetry examination underwent proton magnetic reso-nance spectroscopy (MRS) in L_3 vertebral bodies. The volunteers were divided into five groups according to the age(10 years and 16～18 cases in each group). Results The FF values in 21～30 years group,31～40 years group,41～50 years group,51～60 years group , >60 years group and the osteoporotic group were 30.7%±4.4%, 35.5%±6.8% , 41.9%±6.6%, 46.8%±5.5%, 51.7%±5.2% and 59.2%±7.4%, respectively. The FF values in L_3 vertebral bone marrow in men were high than that in women in the same age group (P<0.05) except >60 years group. There was negative correlation between marrow fat content and T score in osteoporotic group(γ=-0.6, P<0.01). Conclusion The vertebral marrow fat content in healthy adults was significantly in-creased with the aging. MRS may be used as a new way to evaluate the physiological and pathological process of bone marrow.