中国糖尿病杂志
中國糖尿病雜誌
중국당뇨병잡지
CHINESE JOURNAL OF DIABETES
2010年
4期
264-266
,共3页
对氧磷脂酶%糖尿病,2型%基因多态性%氧化型低密度脂蛋白
對氧燐脂酶%糖尿病,2型%基因多態性%氧化型低密度脂蛋白
대양린지매%당뇨병,2형%기인다태성%양화형저밀도지단백
Paraoxonase%Diabetes mellitus，type 2%Polymorphism%Oxidized LDL
目的 探讨对氧磷脂酶(PON)1、PON2基因多态性与T2DM患者氧化型低密度脂蛋白(Ox-LDL)水平的相关性.方法 T2DM患者210例为DM组,健康体检者105名为正常对照(NC)组.两组分别检测Ox-LDL,PON1、PON2基因型.结果 DM组Ox-LDL明显高于NC组(P<0.01),PON1基因QQ型Ox-LDL水平明显高于QR及RR基因型(P＜0.05);PON2基因Ox-LDL水平CC>SC>SS(P＜0.05).多元回归分析表明:HbA1c、PON1基因、PON2基因是血浆Ox-LDL增高的独立危险因素.结论 PON1、PON2基因多态性可能影响2型糖尿病患者Ox-LDL水平.
目的 探討對氧燐脂酶(PON)1、PON2基因多態性與T2DM患者氧化型低密度脂蛋白(Ox-LDL)水平的相關性.方法 T2DM患者210例為DM組,健康體檢者105名為正常對照(NC)組.兩組分彆檢測Ox-LDL,PON1、PON2基因型.結果 DM組Ox-LDL明顯高于NC組(P<0.01),PON1基因QQ型Ox-LDL水平明顯高于QR及RR基因型(P＜0.05);PON2基因Ox-LDL水平CC>SC>SS(P＜0.05).多元迴歸分析錶明:HbA1c、PON1基因、PON2基因是血漿Ox-LDL增高的獨立危險因素.結論 PON1、PON2基因多態性可能影響2型糖尿病患者Ox-LDL水平.
목적 탐토대양린지매(PON)1、PON2기인다태성여T2DM환자양화형저밀도지단백(Ox-LDL)수평적상관성.방법 T2DM환자210례위DM조,건강체검자105명위정상대조(NC)조.량조분별검측Ox-LDL,PON1、PON2기인형.결과 DM조Ox-LDL명현고우NC조(P<0.01),PON1기인QQ형Ox-LDL수평명현고우QR급RR기인형(P＜0.05);PON2기인Ox-LDL수평CC>SC>SS(P＜0.05).다원회귀분석표명:HbA1c、PON1기인、PON2기인시혈장Ox-LDL증고적독립위험인소.결론 PON1、PON2기인다태성가능영향2형당뇨병환자Ox-LDL수평.
Objective To observe the relation of PON1 and PON2 polymorphisms with OxLDL level in T2DM. Methods The levels of OxLDL and PON1 and PON 2 polymorphism were detected in T2DM (n=210) and NC(n=105). Results Plasma OxLDL level in 210 patients with type 2 diabetes mellitus was higher than that in 105 healthy subjects(735.6±356.4 vs 421.1±163.2，P＜0. 01). The OxLDL level in the patients with QQ genotype of paraoxonase1 (PON1) was higher than in QR and RR genotypes (QQ＞QR＞RR:8122±3842 vs 7456±3412 vs 7154±3256,all P＜005).And OxLDL level in the patients with CC genotype of paraoxonase2(PON2) was also higher than in the other 2 genotypes (CC＞SC＞SS:796.5±1765 vs 7544±156.7 vs 731.6±142.4， P＜0.05).Multiple regression analysis showed that HbA1c，PON1 and PON2 were the independent predictors for plasma OxLDL level in type 2 diabetic mellitus. Conclusions PON1 and PON2 gene polymorphisms are genetic factors affecting plasma OxLDL level in type 2 diabetic mellitus.
