CAJ | 학술논문

目的探讨pH对安神补脑液稳定性的影响.方法结合安神补脑液的现行药典标准及HPLC图谱,对加速反应后的不同pH值的安神补脑液进行检测,分析成分的变化规律.结果 pH对安神补脑液中维生素B1、二苯乙烯苷、淫羊藿的黄酮类成分均有影响,pH=5.0～5.5的环境较有利于安神补脑液的稳定.结论 pH对安神补脑液的稳定性有较大的影响,应确定合适的制剂pH范围.
목적 탐토pH대안신보뇌액은정성적영향.방법 결합안신보뇌액적현행약전표준급HPLC도보,대가속반응후적불동pH치적안신보뇌액진행검측,분석성분적변화규률.결과 pH대안신보뇌액중유생소B1、이분을희감、음양곽적황동류성분균유영향,pH=5.0～5.5적배경교유리우안신보뇌액적은정.결론 pH대안신보뇌액적은정성유교대적영향,응학정합괄적제제pH범위.
Objective To investigate the effect of pH value on the stability of Anshen Bunao Liquid. Methods According to the current pharmacopeia standards and the chromatogram of Anshen Bunao Liquid, the preparation with different pH value was detected after accelerated reaction, and the variation regularity of the components was analyzed. Results pH value had an impact on vitamin B1, stilbene glycoside and flavonoid glycoside from An-shen Bunao Liquid. The pH from 5.0 to 5.5 was benefit to the stability of Anshen Bunao Liquid. Conclusions pH has an impact on the stability of Anshen Bunao Liquid, and therefore the pH environment should be proper.