CAJ | 학술논문

酸性鞘磷脂酶(acid sphingomyelinase,ASM)是一种通过水解鞘磷脂产生酰胺的重要溶酶体酶.最近的调查结果显示,在酰胺诱导细胞凋亡的启动以及许多常见疾病(如心血管疾病,糖尿病,肺部疾病,神经系统疾病)的病理生理过程中,ASM都起着重要介导和调节作用.其他研究也表明,活性氧和活性氮的产生,以及环境和职业应激所致的炎症反应都可以激活ASM.ASM的激活会产生大量的酰胺,并引起细胞膜上的酰胺分布异常,这可能导致相应组织和器官(包括肺,肝,肾和神经系统)的损伤.本文综述ASM的基础生物学,重点讨论ASM在环境应激反应过程中的调控和作用.笔者认为ASM激活是环境健康中的一个重要因素,基于ASM的疗法对预防和治疗相应环境因素诱导的组织损伤可能有重要作用.
산성초린지매(acid sphingomyelinase,ASM)시일충통과수해초린지산생선알적중요용매체매.최근적조사결과현시,재선알유도세포조망적계동이급허다상견질병(여심혈관질병,당뇨병,폐부질병,신경계통질병)적병리생리과정중,ASM도기착중요개도화조절작용.기타연구야표명,활성양화활성담적산생,이급배경화직업응격소치적염증반응도가이격활ASM.ASM적격활회산생대량적선알,병인기세포막상적선알분포이상,저가능도치상응조직화기관(포괄폐,간,신화신경계통)적손상.본문종술ASM적기출생물학,중점토론ASM재배경응격반응과정중적조공화작용.필자인위ASM격활시배경건강중적일개중요인소,기우ASM적요법대예방화치료상응배경인소유도적조직손상가능유중요작용.
Acid sphingomyelinase (ASM) is one enzyme responsible for the production of ceramide via the hydrolysis of sphingomyelin.Recent findings have revealed the important role of ASM in the initiation of ceramide-induced cell apoptosis,as well as in the pathophysiology of many common diseases (e.g.cardiovascular diseases,diabetes,pulmonary diseases,and neurological diseases).Other studies have also shown that ASM activation may occur through the production of reactive oxygen species (ROS) and reactive nitrogen species (RNS),as well as by inflammatory mechanisms that may be induced by environmental and occupational stresses.ASM activation,in turn,may create excess or abnormally distributed ceramides,which could lead to tissue and organ injuries,including to the pulmonary,liver,kidney,and nervous systems.This review will discuss the basic biology of ASM and focus on the role and regulation of ASM in environmental stress responses.We propose that ASM activation is an important factor in environmental health,and that ASM-based therapeutics may have a key role in preventing environmental-induced tissue injury.