CAJ | 학술논문

目的观察比较阿司匹林、氯吡格雷及华法林在伴有心房纤颤的缺血性脑卒中患者的卒中二级预防中的疗效.方法将235例伴有心房纤颤的缺血性脑卒中患者按治疗方法的不同随机分为阿司匹林组、氯毗格雷组和华法林组,阿司匹林组给予阿司匹林u服治疗,氯吡格雷组给予氯吡格雷口服治疗、华法林组给予华法林门服治疗,观察3组患者卒中复发率及出血性并发症的概率,进行比较分析.结果随访观察1年,阿司匹林组卒中复发率为15.0%,出血率为2.5%;氯吡格雷组复发率为4.0%,出血率为0;华法林组卒中复发率3.8%,出血率3.8%.结论华法林、氯吡格雷对于伴有心房纤颤的缺血性脑卒中患者卒中的二级预防效果好,安全性高.
목적 관찰비교아사필림、록필격뢰급화법림재반유심방섬전적결혈성뇌졸중환자적졸중이급예방중적료효.방법 장235례반유심방섬전적결혈성뇌졸중환자안치료방법적불동수궤분위아사필림조、록비격뢰조화화법림조,아사필림조급여아사필림u복치료,록필격뢰조급여록필격뢰구복치료、화법림조급여화법림문복치료,관찰3조환자졸중복발솔급출혈성병발증적개솔,진행비교분석.결과 수방관찰1년,아사필림조졸중복발솔위15.0%,출혈솔위2.5%;록필격뢰조복발솔위4.0%,출혈솔위0;화법림조졸중복발솔3.8%,출혈솔3.8%.결론 화법림、록필격뢰대우반유심방섬전적결혈성뇌졸중환자졸중적이급예방효과호,안전성고.
Objective To observe the curative effects of Aspirin,Clopidogrel and Warfarin in the second-level prevention of stroke of ischaemic stroke patients with atrial fibrillation.MethodsA total of 235 cases ischaemic stroke patients with atrial fibrillation were at random divided into Aspirin group,Clopidogrel group and Warfarin group upon different treatment methods.The patients in Aspirin group,Clopidogrel group and Warfarin group were treated by orally taking Aspirin,Clopidogrel and Warfarin respectively.The recurrence rates of stroke and probabilities of hemorrhagic complications in 3 groups were observed,then making a comparative analysis for them.Results After 1-year's follow-up survey,the recurrence rate of stroke in Aspirin group was 15.0% and hemorrhage rate was 2.5% ;the recurrence rate of stroke in Clopidogrel group was 4.0% and hemorrhage rate was O;the recurrence rate of stroke in Warfarin group was 3.8% and hemorrhage rate was 3.8%.Conclusion The use of Warfarin and Clopidogrel in the second-level prevention of stroke of isehaemie stroke patients with atrial fibrillation has good curative effect and high safety.