CAJ | 학술논문

目的观察奥沙利铂(L-OHP)联合亚叶酸钙(CF)和氟尿嘧啶(5-Fu)治疗中晚期食管癌的近期疗效及毒副反应.方法 61例晚期食管癌患者分为治疗组(30例)和对照组(31例).治疗组给予奥沙利铂联合亚叶酸钙和氟尿嘧啶治疗;对照组给予顺铂联合亚叶酸钙和氟尿嘧啶治疗.结果治疗组和对照组的总有效率分别为43.3%和41.9%(P＞0.05).中位疾病进展时间(TTP)分别为8.1个月和7.9个月.毒副反应方面,治疗组血液学毒性、口腔炎、脱发的发生率与对照组均差异无统计学意义(均P＞0.05);Ⅲ～Ⅳ度恶心呕吐(P=0.028),腹泻(P=0.039),肾毒性(P=0.044)等毒副反应发生率均显著低于对照组;外周神经毒性的发生率显著高于对照组(P=0.010).结论奥沙利铂联合亚叶酸钙和氟尿嘧啶治疗中晚期食管癌,疗效较好,且毒副作用较小,可作为一线化疗方案.
목적 관찰오사리박(L-OHP)연합아협산개(CF)화불뇨밀정(5-Fu)치료중만기식관암적근기료효급독부반응.방법 61례만기식관암환자분위치료조(30례)화대조조(31례).치료조급여오사리박연합아협산개화불뇨밀정치료;대조조급여순박연합아협산개화불뇨밀정치료.결과 치료조화대조조적총유효솔분별위43.3%화41.9%(P＞0.05).중위질병진전시간(TTP)분별위8.1개월화7.9개월.독부반응방면,치료조혈액학독성、구강염、탈발적발생솔여대조조균차이무통계학의의(균P＞0.05);Ⅲ～Ⅳ도악심구토(P=0.028),복사(P=0.039),신독성(P=0.044)등독부반응발생솔균현저저우대조조;외주신경독성적발생솔현저고우대조조(P=0.010).결론 오사리박연합아협산개화불뇨밀정치료중만기식관암,료효교호,차독부작용교소,가작위일선화료방안.
Objective To evaluate the efficacy and toxicity of oxaliplatin in combination with calcium folinate and flrDrouracil in treatment of advanced esophageal carcinoma. Methods 61 patients with advanced esophageal cancer were divided into treatment group ( 30 cases) and control group (31 cases). Treatment group was given oxaliplatin combined with calcium folinate and flrorouracil; control group was given cisplatin and calcium folinate and flrorouracil. Results The overall response rate was 43.3% in the treatment group and 41.9% in control group(P＞0.05).The median time to progression( TTP) was 8.1 months vs.7.9 months(P＞0.05).Compared with control group,the treatment group, the side effects of myelosuppression, stomasitis and alopecia were not significant difference (P ＞ 0. 05 ) , grade Ⅰ -Ⅳ nausea and vomiting( P = 0. 028 ) , diarrhea (P = 0. 039 ) and renal toxicity ( P = 0.044 ) were lower,while the peripheral nerve toxicity ( P = 0. 010) was higher. Conclusion The effect of oxaliplatin combined with calcium folinate and flrorouracil had satisfactory effect in the treatment of advanced esophageal carcinoma, and the poisonous side effect was low. It could be used as first-line chemotherapy regimen.