CAJ | 학술논문

目的了解原发性精索静脉曲张合并慢性前列腺炎(CP)者性激素睾酮(Testo)、促黄体生成素(LH)、泌乳素(PRL)水平的变化,探讨性激素在精索静脉曲张合并慢性前列腺炎病理生理中的作用.方法采用化学发光免疫分析法(CIA)检测148例原发性精索静脉曲张合并慢性前列腺炎者的血清性激素水平,其中左侧精索静脉曲张合并前列腺炎者56例,双侧精索静脉曲张合并前列腺炎者92例;148例单纯原发性精索静脉曲张者作为对照,包括56例单纯左侧精索静脉曲张者和92例双侧精索静脉曲张者.结果左侧精索静脉曲张合并慢性前列腺炎组低于对照组性激素T水平(p<0.01),LH水平则高于对照组(p<0.05),PRL水平在两组之间无显著差别.双侧精索静脉曲张合并慢性前列腺炎组高于对照组的性激素T水平(p<0.01),而PRL水平低于对照组(p<0.01),LH水平在两组之间无显著差别(p>0.05).单纯左侧精索静脉曲张与双侧精索静脉曲张组比较,性激素T水平下降(p<0.01),LH水平升高(p<0.05),PRL水平无显著差异.结论精索静脉曲张及慢性前列腺炎(CP)与性激素分泌失衡的发生发展有密切关系;其具体机制尚需进一步研究.
목적 료해원발성정색정맥곡장합병만성전렬선염(CP)자성격소고동(Testo)、촉황체생성소(LH)、비유소(PRL)수평적변화,탐토성격소재정색정맥곡장합병만성전렬선염병리생리중적작용.방법 채용화학발광면역분석법(CIA)검측148례원발성정색정맥곡장합병만성전렬선염자적혈청성격소수평,기중좌측정색정맥곡장합병전렬선염자56례,쌍측정색정맥곡장합병전렬선염자92례;148례단순원발성정색정맥곡장자작위대조,포괄56례단순좌측정색정맥곡장자화92례쌍측정색정맥곡장자.결과 좌측정색정맥곡장합병만성전렬선염조저우대조조성격소T수평(p<0.01),LH수평칙고우대조조(p<0.05),PRL수평재량조지간무현저차별.쌍측정색정맥곡장합병만성전렬선염조고우대조조적성격소T수평(p<0.01),이PRL수평저우대조조(p<0.01),LH수평재량조지간무현저차별(p>0.05).단순좌측정색정맥곡장여쌍측정색정맥곡장조비교,성격소T수평하강(p<0.01),LH수평승고(p<0.05),PRL수평무현저차이.결론 정색정맥곡장급만성전렬선염(CP)여성격소분비실형적발생발전유밀절관계;기구체궤제상수진일보연구.
Objectives To investigate the possible role reproductive hormones plays in the pathophysiology of varicocele associated with chronic prostatitis after observation on the difference of reproductive hormones , including LH , PRL and T , in the cases with varicocele and varicocele associated with chronic prostatitis. Methods Reproductive hormones of 148 varicocele associated with chronic prostatitis cases including 56 left varicocele associated with prostatitis cases and 92 bilateral varicocele associated with prostatitis cases were detected by using time-resolved fluorescent immunoassay , and 148 varicoceled patients including 56 left varicocele cases and 92 bilateral varicocele cases as controls. Results The plasma T levels in left varicocele associated with prostatitis group is lower than that in control group( p <0.01 ) , the plasma LH levels in left varicocele associated with prostatitis group is higher than that in control group( p <0.01) , but the plasma PRL levels had no significant difference between them . The plasma T levels in bilateral varicocele associated with prostatitis group is higher than that in control group( p < 0.01) , the plasma PRL levels in bilateral varicocele associated with prostatitis group is lower than that in control group ( p <0.01) , but the plasma LH levels had no significant difference between them . The levels of T in the left varicocele group was higher than that in the bilateral varicocele group( p <0.01 ). The levels of LH in the left varicocele group was lower than that in the bilateral varicocele group ( p < 0.05 ). There was no significant difference between the left varicocele group and bilateral varicocele group in the levels of PRL. Conclusions The changes of reproductive hormone levels was related closely to the varicocele and chronic prostatitis , but its needed to furhtur investigate in the specific pathogenesis.