CAJ | 학술논문

研究表明,离子通道CRAC、Kv1.3、KCa3.1、Clswell等共同在T淋巴细胞活化及稳态中发挥作用,参与机体免疫调节.钙离子通过T淋巴细胞膜上的CRAC进入细胞内,作为第二信使激活T淋巴细胞.钾离子通道介导的钾离子外流是T淋巴细胞膜电位形成的基础,间接调节T淋巴细胞的活化和功能.T淋巴细胞膜上的氯离子通道与细胞的体积调节有关.了解离子通道表达改变所引起T细胞亚型的分化,T细胞离子通道在T细胞活化中的作用及离子通道阻断剂用于治疗自身免疫疾病及过敏反应的可能性具有重要意义.
연구표명,리자통도CRAC、Kv1.3、KCa3.1、Clswell등공동재T림파세포활화급은태중발휘작용,삼여궤체면역조절.개리자통과T림파세포막상적CRAC진입세포내,작위제이신사격활T림파세포.갑리자통도개도적갑리자외류시T림파세포막전위형성적기출,간접조절T림파세포적활화화공능.T림파세포막상적록리자통도여세포적체적조절유관.료해리자통도표체개변소인기T세포아형적분화,T세포리자통도재T세포활화중적작용급리자통도조단제용우치료자신면역질병급과민반응적가능성구유중요의의.
It has been proved that Kv1.3,KCa3.1,CRAC,and Clswell comprise a network that performs functions vital for cellular homeostasis and T-cell activation.It also play an important role in immune regulation.The influx of Ca2+ into T lymphocyte through CRAC may act as a second messenger to activate T lymphocyte.The efflux of K+ from T lymphocyte through the K + channel contributes to the formation of T cell membrane potential.Therefore,the activation and the functions of T cell can be regulated by K + channel indirectly.Clswell channel in T lymphocyte is involved in the regulation of cell volume.We discuss the differentiation of T cell subtypes induced by the expression changes of ion channels,the ion channels expressed in T cells and their function in T cell activation.In addition,some ion channel blockers with a potential effect on the treatment of autoimmune disorders and anaphylactic reactions are also discussed.