CAJ | 학술논문

慢性肾脏病在病理上大多表现为间质炎症细胞浸润及纤维化,进而致肾功能进行性退化,最终不可避免地进展为终末期肾病.其中中晚期肾脏的进行性损害主要与肾间质微血管的丢失有关.鉴于肾间质微血管病变与慢性肾脏病的进展关系密切,该文从肾间质微血管内皮细胞的损伤、修复及其干预策略三个层次综述其与慢性肾脏病的关系,旨在对慢性肾脏病的认识、干预及治疗有所裨益.
만성신장병재병리상대다표현위간질염증세포침윤급섬유화,진이치신공능진행성퇴화,최종불가피면지진전위종말기신병.기중중만기신장적진행성손해주요여신간질미혈관적주실유관.감우신간질미혈관병변여만성신장병적진전관계밀절,해문종신간질미혈관내피세포적손상、수복급기간예책략삼개층차종술기여만성신장병적관계,지재대만성신장병적인식、간예급치료유소비익.
Most chronic kidney diseases are complicated by tubulointerstitial inflammation and fibrosis,leading to progressive deterioration of renal function,and potentially ultimately resulting in irreversible end-stage kidney.And the advanced tubulointerstitial damage is often associated with the lose of peritubular capillaries.With the close relationship of the lose of peritubular capillaries and the progress of chronic kidney diseases,this review reprents the relationship of endothelium and the progress of chronic kidney diseases through three levels including endothelial injury,repairment,and relative intervention,in order to aid in the recognition,intervention and therapy of chronic kidney diseases.