CAJ | 학술논문

收集本院2006年1月至2009年6月收治的338例2型糖尿病患者,同时设置50例健康对照组,检测两组血小板膜糖蛋白PAC-1、CD62P水平,结果显示,与正常对照组比较,2型糖尿病患者PAC-1、CD62P表达明显升高(P＜0.01);将2型糖尿病患者进一步按尿白蛋白排泄率(UAER)分组,结果示大量白蛋白尿组(UAER≥200μg/min)PAC-1、CD62P表达明显高于UAER正常组(UAER＜20μg/min)、微量白蛋白尿组(20μg/min≤UAER＜200μg/min)(均P＜0.05).血小板活化的PAC-1、CD62P表达是糖尿病肾病的独立危险因素(OR值分别为1.055,1.064,均P＜0.05).
수집본원2006년1월지2009년6월수치적338례2형당뇨병환자,동시설치50례건강대조조,검측량조혈소판막당단백PAC-1、CD62P수평,결과현시,여정상대조조비교,2형당뇨병환자PAC-1、CD62P표체명현승고(P＜0.01);장2형당뇨병환자진일보안뇨백단백배설솔(UAER)분조,결과시대량백단백뇨조(UAER≥200μg/min)PAC-1、CD62P표체명현고우UAER정상조(UAER＜20μg/min)、미량백단백뇨조(20μg/min≤UAER＜200μg/min)(균P＜0.05).혈소판활화적PAC-1、CD62P표체시당뇨병신병적독립위험인소(OR치분별위1.055,1.064,균P＜0.05).
Three hundred and thirty eight patients with type 2 diabetes mellitus( DM) admitted from January 2006 to June 2009 and 50 healthy subjects (control group) were enrolled in the study. Platelet glycoprotein PAC-1 and CD62P levels were measured in both groups. Compared with control group, plasma PAC-1 and CD62P levels of DM patients increased significantly (P ＜0.01). Patients were divided into three groups according to their urinary albumin excretion rate ( UAER) . PAC-1 and CD62P levels in macroalbuminuria group (UAER≥200μg/min) were significantly higher than those in normoalbuminuria group( UAER <20μg/min) and microalbuminuria group (20μg/min≤UAER ＜ 200μg/min) (both P＜ 0.05). The results indicate that plasma levels of PAC-1 and CD62P, which reflect platelet activation, are the independent risk factors for diabetic nephropathy.