中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2009年
2期
22-24
,共3页
心肌梗死%血栓溶解疗法%前胶原%左心功能
心肌梗死%血栓溶解療法%前膠原%左心功能
심기경사%혈전용해요법%전효원%좌심공능
Myocardial infarction%Thrombolytic therapy%Procollagen%Left ventricular function
目的 观察早期静脉溶栓与非溶栓治疗对老年急性心肌梗死(AMI)患者血清Ⅲ型前胶原水平及左心功能的影响.方法 将56例AMI患者分为静脉溶栓组(29例)和非溶栓组(27例),应用放射免疫法测定血清Ⅲ型前胶原末端肽(PⅢP)含量,采用彩色Doppler超声心动图仪测量左室结构及舒缩功能参数.结果 溶栓组患者在溶栓开始后1、2、4、6周血清PⅢP含量分别为(92±14)、(90±11)、(86±8)和(82±7)μg/L,较同期非溶栓组患者PⅢP(118±11)、(112±11)、(104±11)和(95±9)μg/L明显降低(P＜0.05或P＜0.01);溶栓未再通组血清PⅢP含量显著高于再通组(P＜0.05或P＜0.01).血清PⅢP含量与左室重塑(LVRM)程度有良好的相关性(r=0.4314,P＜0.05),与左室舒缩功能呈负相关(r=-0.4233,P＜0.05;r=-0.4542,P＜0.05).结论 早期实施静脉溶栓治疗能降低AMI患者血清PⅢP水平,减少LVRM发生,改善患者左心功能.
目的 觀察早期靜脈溶栓與非溶栓治療對老年急性心肌梗死(AMI)患者血清Ⅲ型前膠原水平及左心功能的影響.方法 將56例AMI患者分為靜脈溶栓組(29例)和非溶栓組(27例),應用放射免疫法測定血清Ⅲ型前膠原末耑肽(PⅢP)含量,採用綵色Doppler超聲心動圖儀測量左室結構及舒縮功能參數.結果 溶栓組患者在溶栓開始後1、2、4、6週血清PⅢP含量分彆為(92±14)、(90±11)、(86±8)和(82±7)μg/L,較同期非溶栓組患者PⅢP(118±11)、(112±11)、(104±11)和(95±9)μg/L明顯降低(P＜0.05或P＜0.01);溶栓未再通組血清PⅢP含量顯著高于再通組(P＜0.05或P＜0.01).血清PⅢP含量與左室重塑(LVRM)程度有良好的相關性(r=0.4314,P＜0.05),與左室舒縮功能呈負相關(r=-0.4233,P＜0.05;r=-0.4542,P＜0.05).結論 早期實施靜脈溶栓治療能降低AMI患者血清PⅢP水平,減少LVRM髮生,改善患者左心功能.
목적 관찰조기정맥용전여비용전치료대노년급성심기경사(AMI)환자혈청Ⅲ형전효원수평급좌심공능적영향.방법 장56례AMI환자분위정맥용전조(29례)화비용전조(27례),응용방사면역법측정혈청Ⅲ형전효원말단태(PⅢP)함량,채용채색Doppler초성심동도의측량좌실결구급서축공능삼수.결과 용전조환자재용전개시후1、2、4、6주혈청PⅢP함량분별위(92±14)、(90±11)、(86±8)화(82±7)μg/L,교동기비용전조환자PⅢP(118±11)、(112±11)、(104±11)화(95±9)μg/L명현강저(P＜0.05혹P＜0.01);용전미재통조혈청PⅢP함량현저고우재통조(P＜0.05혹P＜0.01).혈청PⅢP함량여좌실중소(LVRM)정도유량호적상관성(r=0.4314,P＜0.05),여좌실서축공능정부상관(r=-0.4233,P＜0.05;r=-0.4542,P＜0.05).결론 조기실시정맥용전치료능강저AMI환자혈청PⅢP수평,감소LVRM발생,개선환자좌심공능.
Objective To study the serum concentration of pro-collagen Ⅲ(PⅢP)and left ventricular function in acute myocardial infarction(AMI)patients with or without thrombolytic treatment.Methods The 56 patients with AMI were randomly divided into thrombolysis group(n=29)and non-thrombolysis group(n=27).The serum concentration of PⅢP were measured by specific radioimmunoassay.Two-dimensional,M-mode and Doppler ultrasound recordings were obtained from all patients to determine several parameters relating to the left ventricular anatomy and function.Results In comparison with non-thromblysis group at 1st,2nd,4th,6th week after treatment,serum concentrations of PⅢP was significantly decreased in patients of thrombolysis group[(92±14),(90±11),(86±8)and(82±7)μg/L vs(118±11),(112±11),(104±11)and(95±9)μg/L,P＜0.05 or P＜0.01].PⅢP was significantly increased in non-reperfusion group than that of the reperfusion group.PⅢP was correlated positively with left ventricular remodeling(LVRM)(r=0.4314,P＜0.05),and negatively with the left ventricular diastolic and systolic function(r=-0.4233,P＜0.05;r=-0.4542,P＜0.05).Conclusions The early intravenous thrombolytic therapy can improve left ventricular function,and decrease serum PⅢP and reduce LVRM.
