CAJ | 학술논문

目的探讨吲哚胺2,3双加氧酶(IDO)在乳腺癌中的表达及其与乳腺癌临床病理特征、预后的关系.方法收集40例乳腺癌蜡块,应用免疫组化SP法检测乳腺癌组织中IDO的表达,并对全部标本用CD31和CD105对肿瘤血管内皮细胞进行染色,计数肿瘤微血管密度(MVD),结合患者的临床病理特征及预后进行分析.结果乳腺癌组织中IDO蛋白高表达率为67.5%(27/40),其表达与临床分期和淋巴结转移相关(均P＜0.05).IDO高表达组与低表达组的3年、 5年无瘤生存率差异均无统计学意义(P=0.211,P=0.523).乳腺癌组织中IDO表达与CD105标记的MVD值呈正相关(r=0.659,P＜0.05),与CD31标记的MVD值无关.结论 IDO可能通过促进新生血管形成加速乳腺癌的进展和转移,IDO表达与乳腺癌患者预后的关系需要进一步扩大样本量加以明确.
목적 탐토신타알2,3쌍가양매(IDO)재유선암중적표체급기여유선암림상병리특정、예후적관계.방법 수집40례유선암사괴,응용면역조화SP법검측유선암조직중IDO적표체,병대전부표본용CD31화CD105대종류혈관내피세포진행염색,계수종류미혈관밀도(MVD),결합환자적림상병리특정급예후진행분석.결과 유선암조직중IDO단백고표체솔위67.5%(27/40),기표체여림상분기화림파결전이상관(균P＜0.05).IDO고표체조여저표체조적3년、 5년무류생존솔차이균무통계학의의(P=0.211,P=0.523).유선암조직중IDO표체여CD105표기적MVD치정정상관(r=0.659,P＜0.05),여CD31표기적MVD치무관.결론 IDO가능통과촉진신생혈관형성가속유선암적진전화전이,IDO표체여유선암환자예후적관계수요진일보확대양본량가이명학.
Objective To investigate the expression of indoleamine 2,3-dioxygenase (IDO) in breast cancer and its correlation with clinicopathologic factors and prognosis. Methods The expression of IDO, CD31, CD105 proteins in 40 specimens of breast cancer were assessed by immunohistochemistry. Results The overexpression rate of IDO in breast cancer was 67.5% (27/40), and expression of IDO was closely associated with clinical stage and lymph nodes metastasis. The disease-free survival rate in patients with IDO overexpression was not significantly lower than that in patients with negative or low expression of IDO(P>0.05). Moreover, the expression of IDO was positively correlated with CD105-labeled microvessel density (r=0.659,P<0.05). Conclusions Expression of IDO is associated with clinical stage and lymph nodes metastasis, and microvessel densitty. IDO expression may promote the growth and metastasis of breast cancer, probably via the increased agiogenesis. A larger sample study is needed to verify whether the prognosis of beast cancer is significantly correlated with IDO expression.