CAJ | 학술논문

目的以羟丙甲纤维素(HPMC)为骨架材料制备持续释药12h的磷酸川芎嗪缓释片。方法分别采用中国药典1995年版溶出度测定法第2法及高效液相色谱法测定缓释片的体外释放度及兔体内生物利用度。结果缓释片体外1h释药20％左右，12h释药85％以上，12 h内释药平稳，释药曲线符合Higuchi方程，体外释药受HPMC类型、黏度、用量影响较大。缓释片与市售常释片相比，兔体内峰浓度降低，达峰时间延迟，平均滞留时间延长，吸收程度生物等效。结论缓释片体内外缓释效果良好，并具有良好的体内外相关性。
목적 이간병갑섬유소(HPMC)위골가재료제비지속석약12h적린산천궁진완석편。방법 분별채용중국약전1995년판용출도측정법제2법급고효액상색보법측정완석편적체외석방도급토체내생물이용도。결과 완석편체외1h석약20％좌우，12h석약85％이상，12 h내석약평은，석약곡선부합Higuchi방정，체외석약수HPMC류형、점도、용량영향교대。완석편여시수상석편상비，토체내봉농도강저，체봉시간연지，평균체류시간연장，흡수정도생물등효。결론 완석편체내외완석효과량호，병구유량호적체내외상관성。
Purpose To prepare the sustained-release tablet of tetramethylpyrazine phosphate with hydroxypropylmethylcelluose(HPMC) as matrix material. Methods The paddle method and the HPLC method were erspectively used determined the cumulative drug released in vitro and the serum concentration in vivo. Results The cumulative drug released in the first hour was about 20%, while in 12 hours it was above 85%. Drug release behavior can be best described by Higuchi equation, and the release rate decreased as the viscosity and/or the amount of HPMC increased. Compared with the market tablet on the rabbits, the sustained release tablet had the decreased peak concentration (P < 0.05 ); the prolonged peak time and mean residence time (P< 0.05). Conclusions The matrix tablet was a good sustained-release dosage form and it had a good in vitro-in vivo correlation.