CAJ | 학술논문

通过热力学计算证明, 超声在生物组织中的粘滞耗散和热耗散引起的吸收低于化学弛豫引起的非经典吸收,低频低强度的超声吸收在生物组织中的熵产生对于癌细胞和正常细胞是不同的,这种不同联系于二者的酸度差异.理论计算证明, 低频低强度的超声照射可以导致癌细胞和正常细胞熵产生率的倒转,从而可以改变熵流方向,抑止癌的毒性信息流的扩散.这提供了癌症理疗的一个新方案.
통과열역학계산증명, 초성재생물조직중적점체모산화열모산인기적흡수저우화학이예인기적비경전흡수,저빈저강도적초성흡수재생물조직중적적산생대우암세포화정상세포시불동적,저충불동련계우이자적산도차이.이론계산증명, 저빈저강도적초성조사가이도치암세포화정상세포적산생솔적도전,종이가이개변적류방향,억지암적독성신식류적확산.저제공료암증리료적일개신방안.
Entropy production of tumor cells is higher than that of normal cells,therefore entropy current is directed from tumor towards healthy cells.However,ultrasound absorption results in additional entropy production in tissues.The differences in ultrasonic absorption are related to pH since tumor is more acidic than normal tissue around the tumor.We demonstrated that the ultrasound absorption will increase the entropy in normal tissue more efficiently than in the tumor.Consequently the direction of entropy flow between two kind of cells may be reversed under the irradiation of ultrasound.Entropy flows from healthy tissue to cancerous tissue after ultrasonic treatment can contribute to the formation of barrier between the two different tissues,blocking the propagation of harmful information of cancer into normal tissue.Based on above studies we suggest that the low intensity (several percents of 1 Watt/cm2) and low frequency (1 MHz or lower) ultrasound irradiation may be an efficient tool for the physiotherapy of solid tumors.