CAJ | 학술논문

目的观察鼻咽癌(NPC)组织中pI3K、p-Akt和PTEN表达,探讨它们在鼻咽癌发生中的作用.方法应用免疫组化方法检测60例NPC组织和23例鼻咽部慢性炎症组织中pI3K、p-Akt和PTEN的表达.结果 NPC与慢性炎症组pI3K的表达率分别为86.7%(52/60)和60.9%(14/23) (P<0.05);p-Akt表达率分别为76.7%(46/60)和47.8%(11/23)(P<0.05);PTEN的表达率分别为41.7% (25/60)和65.2%(15/23) (P<0.01).pI3K/p-Akt表达率NPC组明显高于慢性炎症组;PTEN表达率NPC组明显低于慢性炎症组,二组表达均与PTEN表达呈负相关.结论 pI3K/Akt信号通路的激活、PTEN的抑制,可能在鼻咽癌的发生中起重要作用.
목적 관찰비인암(NPC)조직중pI3K、p-Akt화PTEN표체,탐토타문재비인암발생중적작용.방법 응용면역조화방법검측60례NPC조직화23례비인부만성염증조직중pI3K、p-Akt화PTEN적표체.결과 NPC여만성염증조pI3K적표체솔분별위86.7%(52/60)화60.9%(14/23) (P<0.05);p-Akt표체솔분별위76.7%(46/60)화47.8%(11/23)(P<0.05);PTEN적표체솔분별위41.7% (25/60)화65.2%(15/23) (P<0.01).pI3K/p-Akt표체솔NPC조명현고우만성염증조;PTEN표체솔NPC조명현저우만성염증조,이조표체균여PTEN표체정부상관.결론 pI3K/Akt신호통로적격활、PTEN적억제,가능재비인암적발생중기중요작용.
Objective To investigate the expression of PI3K, pAkt and PTEN, and to evaluate their effects on the tumorigenesis in nasopharyngeal carcinoma. Methods Immunohistochemical methods were adopted to examine the expression of PI3K, Akt and PTEN in 60 cases of nasopharyngeal carcinomas and 23 non-tumor nasopharyngeal tissue. Results In NPC and non-tumor cases, positive rates of PI3K were 86.7%(52/60)and 60.9%(14/23) (P<0.05), that of p-Akt were 76.7%(46/60)and 47.8%(11/23)(P<0.05), and that of PTEN 41.7% (25/60) and 65.2%(15/23) (P<0.01), respectively. Expression rates of PI3K/p-Akt in the NPC were significantly higher than the non-tumor, and that of PTEN in the NPC were significantly lower than the non-tumor. Conclusion The activation of PI3K/Akt pathway and the inhibition of PTEN expression may play important roles in the tumorigenesis and progression of nasopharyngeal carcinoma.