精细石油化工
精細石油化工
정세석유화공
SPECIALITY PETROCHEMICALS
2009年
6期
19-21
,共3页
乙酰水杨酰胺%傅克酰基化反应%离子液体%水杨酰胺%乙酰氯
乙酰水楊酰胺%傅剋酰基化反應%離子液體%水楊酰胺%乙酰氯
을선수양선알%부극선기화반응%리자액체%수양선알%을선록
5-acetylsalicylamide%Friedel-Crafts acetylation%ionic liquid%salicylamide%acetyl chloride
实验以盐酸三乙胺-三氯化铝离子液体(IL)为催化剂,催化水杨酰胺(SA)与乙酰氯进行傅克酰基化反应合成5-乙酰水杨酰胺.讨论了离子液体与水杨酰胺摩尔比、乙酰氯与水杨酰胺摩尔比、反应温度与反应时间等因素对水杨酰胺酰基化合成5-乙酰水杨酰胺的影响,最佳反应条件为:n(IL):n(SA)=2:1,n(乙酰氯):n(SA)=4:1,反应温度40℃,反应时间120 min.在上述最佳条件下,不使用有机溶剂,水杨酰胺的转化率为99.1%,乙酰水杨酰胺的收率达到了73.1%.
實驗以鹽痠三乙胺-三氯化鋁離子液體(IL)為催化劑,催化水楊酰胺(SA)與乙酰氯進行傅剋酰基化反應閤成5-乙酰水楊酰胺.討論瞭離子液體與水楊酰胺摩爾比、乙酰氯與水楊酰胺摩爾比、反應溫度與反應時間等因素對水楊酰胺酰基化閤成5-乙酰水楊酰胺的影響,最佳反應條件為:n(IL):n(SA)=2:1,n(乙酰氯):n(SA)=4:1,反應溫度40℃,反應時間120 min.在上述最佳條件下,不使用有機溶劑,水楊酰胺的轉化率為99.1%,乙酰水楊酰胺的收率達到瞭73.1%.
실험이염산삼을알-삼록화려리자액체(IL)위최화제,최화수양선알(SA)여을선록진행부극선기화반응합성5-을선수양선알.토론료리자액체여수양선알마이비、을선록여수양선알마이비、반응온도여반응시간등인소대수양선알선기화합성5-을선수양선알적영향,최가반응조건위:n(IL):n(SA)=2:1,n(을선록):n(SA)=4:1,반응온도40℃,반응시간120 min.재상술최가조건하,불사용유궤용제,수양선알적전화솔위99.1%,을선수양선알적수솔체도료73.1%.
Friedel-Crafts acetylation of salicylamide (SA) with acetyl chloride to 5-acetylsalicylamide using triethylammonium chloroaluminate ionic liquid (IL) as both catalyst and solvent was investigated. The effects of the molar ratios of ionic liquid to salicylamide and acetyl chloride to salicylamide, reaction temperature and reaction time on the acetylation were studied. The optimal reaction conditions were: n(IL):n(SA)=2 : 1, n(acetyl chloride): n(SA)=4 :1, reaction temperature 40 ℃, and reaction time 120 min in the absence of organic solvent. The conversion of salicylamide was 99.1% and the yield of 5-acetylsalicylamide was up to 73.1%.
