CAJ | 학술논문

研究宫内感染的机制对降低我国HBsAg慢性携带率具有非常重要的意义.妊娠过程中母体血液中的血小板和白细胞可通过胎盘屏障,而胎盘细胞凋亡与胎盘屏障通透性增加又存在不可分割的内在联系,PBMC是HBV肝外感染的主要细胞,在HBV复制、感染及迁延中起着重要作用,可以作为HBV的载体.这些证据提示PBMC母胎转运在HBV宫内感染中可能具有不容忽视的作用.此文对HBV宫内感染的定义及判定指标、感染的机制及危险因素、母胎PBMC转运机制与感染的关系等进行综述.
연구궁내감염적궤제대강저아국HBsAg만성휴대솔구유비상중요적의의.임신과정중모체혈액중적혈소판화백세포가통과태반병장,이태반세포조망여태반병장통투성증가우존재불가분할적내재련계,PBMC시HBV간외감염적주요세포,재HBV복제、감염급천연중기착중요작용,가이작위HBV적재체.저사증거제시PBMC모태전운재HBV궁내감염중가능구유불용홀시적작용.차문대HBV궁내감염적정의급판정지표、감염적궤제급위험인소、모태PBMC전운궤제여감염적관계등진행종술.
It has great significance to study mechanism of intrauterine infection in reducing the chronic HBsAg carrier rate in China.Maternal blood platelets and white blood cells can pass through the placental barrier during pregnancy.The indivisible intrinsic link exists between placental apoptosis and placental barrier permeability increase.PBMC is mainly extrahepatic cells in HBV infection,it plays an important role in HBV replication,and persistent infection.It may be as carriers of HBV.The evidence suggests that role of maternal-fetal PBMC transfer in HBV intrauterine infection can not be ignored.In this paper,the definity and diagnostic index of HBV intrauterine infection,the infected mechanisms and risk factors,the relation between maternal-fetal transfer mechanisms of PBMC and the infection are reviewed.