国际放射医学核医学杂志
國際放射醫學覈醫學雜誌
국제방사의학핵의학잡지
INTERNATIONAL JOURNAL OF RADIATION MEDICINE AND NUCLEAR MEDICINE
2010年
2期
97-99
,共3页
胡红永%汤建林%李玉莹%高柳燕%唐秀萍
鬍紅永%湯建林%李玉瑩%高柳燕%唐秀萍
호홍영%탕건림%리옥형%고류연%당수평
结直肠肿瘤%癌胚抗原%CA-19-9抗原%CA-242抗原%放射免疫测定
結直腸腫瘤%癌胚抗原%CA-19-9抗原%CA-242抗原%放射免疫測定
결직장종류%암배항원%CA-19-9항원%CA-242항원%방사면역측정
Colorectal neoplasms%Carcinoembryonic antigen%CA-19-9 antigen%CA-242 antigen%Radioimmunoassay
目的 探讨云南省大理州结直肠癌患者血清中肿瘤标志物癌胚抗原(CEA)、糖链蛋白抗原19-9(CA19-9)、糖链蛋白抗原242(CA242)单项或多项联检对结直肠癌的临床诊断价值.方法 应用电化学发光法和放免法检测89例结直肠癌患者和50例正常体检者的CEA、CA19-9和CA242水平.结果 三种肿瘤标志物在结直肠癌患者血清中含量均明显高于健康对照组(t分别为2.97、3.55和7.44,P均＜0.01);三种肿瘤标志物联检对结直肠癌的临床诊断效果明显优于各单项(CEA、CA19-9、CA242)和两项联检(CA242+CA19-9和CEA+CA19-9),差异有统计学意义(X2分别为30.552、32.076、18.365、7.130和8.862,P均＜0.01);三项联检可提高结直肠癌诊断的灵敏度(85.39%)和准确率(90.60%),但特异度下降(88.00%).结论 CEA、CA19-9和CA242可用于该地区结直肠痛的早期诊断和病情判断,三者联检可提高诊断效率.
目的 探討雲南省大理州結直腸癌患者血清中腫瘤標誌物癌胚抗原(CEA)、糖鏈蛋白抗原19-9(CA19-9)、糖鏈蛋白抗原242(CA242)單項或多項聯檢對結直腸癌的臨床診斷價值.方法 應用電化學髮光法和放免法檢測89例結直腸癌患者和50例正常體檢者的CEA、CA19-9和CA242水平.結果 三種腫瘤標誌物在結直腸癌患者血清中含量均明顯高于健康對照組(t分彆為2.97、3.55和7.44,P均＜0.01);三種腫瘤標誌物聯檢對結直腸癌的臨床診斷效果明顯優于各單項(CEA、CA19-9、CA242)和兩項聯檢(CA242+CA19-9和CEA+CA19-9),差異有統計學意義(X2分彆為30.552、32.076、18.365、7.130和8.862,P均＜0.01);三項聯檢可提高結直腸癌診斷的靈敏度(85.39%)和準確率(90.60%),但特異度下降(88.00%).結論 CEA、CA19-9和CA242可用于該地區結直腸痛的早期診斷和病情判斷,三者聯檢可提高診斷效率.
목적 탐토운남성대리주결직장암환자혈청중종류표지물암배항원(CEA)、당련단백항원19-9(CA19-9)、당련단백항원242(CA242)단항혹다항련검대결직장암적림상진단개치.방법 응용전화학발광법화방면법검측89례결직장암환자화50례정상체검자적CEA、CA19-9화CA242수평.결과 삼충종류표지물재결직장암환자혈청중함량균명현고우건강대조조(t분별위2.97、3.55화7.44,P균＜0.01);삼충종류표지물련검대결직장암적림상진단효과명현우우각단항(CEA、CA19-9、CA242)화량항련검(CA242+CA19-9화CEA+CA19-9),차이유통계학의의(X2분별위30.552、32.076、18.365、7.130화8.862,P균＜0.01);삼항련검가제고결직장암진단적령민도(85.39%)화준학솔(90.60%),단특이도하강(88.00%).결론 CEA、CA19-9화CA242가용우해지구결직장통적조기진단화병정판단,삼자련검가제고진단효솔.
Objective To explore the clinical value of serum tumor markers carcinoembryonic antigen (CEA), carbohydrate antigen 19-9(CA19-9) and carbohydrate antigen 242(CA242) levels in patients with colorectal cancer using single item and multi-items determination. Methods Serum levels of CEA, CA19-9 and CA242 were measured with chemiuminescent immunoassay (CLIA) and radioimmunoassay (RIA) in 89 cases of colorectal cancer patients and 50 cases of normal people. Results The serum levels of this three tumor markers were significantly higher than those in the control group (t=2.97, 3.55 and 7.44, P＜0.01). Combined determination of those three obviously excels that two items (CA242+CA19-9 and CEA+CA19-9) or single item, there was statistical significance (x2=30.552, 32.076, 18.365, 7.130 and 8.862, P＜0.01). Combined determination of those three could enhance the sensitivity (85.39%) and accuracy(90.60%), but the specificity was decreased (88.00%). Conclusion Determination of serum CEA, CA19-9 and CA242 levels are valuable for the diagnosis and evaluation of patients with colorectal cancer, and the diagnosis sensitivity can be enhanced with combined determinations.
