中华肝脏病杂志
中華肝髒病雜誌
중화간장병잡지
CHINESE JOURNAL OF HEPATOLOGY
2009年
7期
535-539
,共5页
彭仙娥%赖智双%陆青青%林建银%林旭
彭仙娥%賴智雙%陸青青%林建銀%林旭
팽선아%뢰지쌍%륙청청%림건은%림욱
脂肪肝%危险因素%病例对照研究
脂肪肝%危險因素%病例對照研究
지방간%위험인소%병례대조연구
Fatty liver%Risk factors%Case-control studies
目的 调查非酒精性脂肪性肝病(NAFLD)发病的影响因素,为预防NAFLD的发生提供可靠的流行病学依据.方法 采用病例对照研究方法,对福建医科大学附属协和医院2007年1-8月体检确诊的NAFLD患者385例和同期的体检健康人群825人进行调查.自制调查表收集两组一般情况、生活方式、饮食习惯、疾病既往史及生物化学检查结果,并对过程进行质量控制.两组间均衡检验采用t检验和χ2检验;单因素分析采用χ2检验;采用非条件Logistic逐步回归分析筛选变量,找出NAFLD的影响因素.结果 两组在饮酒量(g/周)、是否喝茶、是否吸烟、运动指数、进餐速度、应酬频率、食用油种类、是否食用海产品、是否有脂肪肝家族史及是否有高血压,血糖增高、血脂异常、ALT增高、AST增高、高尿酸血症、肥胖、高密度脂蛋白降低、低密度脂蛋白增高18个方面的差异有统计学意义(P值均＜0.05).非条件Logistic逐步回归分析结果显示,以上18个因素中有12个因素进入模型,其中肥胖(OR=6.35)、高血压(OR=3.82)、血脂异常(OR=2.95)、高密度脂蛋白降低(OR=2.85)、高血糖(OR=2.82)、ALT增高(OR=2.80)、高尿酸血症(OR=2.35)、HBsAg阳性(OR=1.99)、脂肪肝家族史(OR=1.79)及常吃海产品(OR=1.58)是NAFLD的危险因素,而饮茶(OR=0.72)和经常运动(OR=0.90)则是NAFLD的保护因素. 结论 影响NAFLD发病的因素有多种,主要是生活方式,与遗传因素也有关.
目的 調查非酒精性脂肪性肝病(NAFLD)髮病的影響因素,為預防NAFLD的髮生提供可靠的流行病學依據.方法 採用病例對照研究方法,對福建醫科大學附屬協和醫院2007年1-8月體檢確診的NAFLD患者385例和同期的體檢健康人群825人進行調查.自製調查錶收集兩組一般情況、生活方式、飲食習慣、疾病既往史及生物化學檢查結果,併對過程進行質量控製.兩組間均衡檢驗採用t檢驗和χ2檢驗;單因素分析採用χ2檢驗;採用非條件Logistic逐步迴歸分析篩選變量,找齣NAFLD的影響因素.結果 兩組在飲酒量(g/週)、是否喝茶、是否吸煙、運動指數、進餐速度、應酬頻率、食用油種類、是否食用海產品、是否有脂肪肝傢族史及是否有高血壓,血糖增高、血脂異常、ALT增高、AST增高、高尿痠血癥、肥胖、高密度脂蛋白降低、低密度脂蛋白增高18箇方麵的差異有統計學意義(P值均＜0.05).非條件Logistic逐步迴歸分析結果顯示,以上18箇因素中有12箇因素進入模型,其中肥胖(OR=6.35)、高血壓(OR=3.82)、血脂異常(OR=2.95)、高密度脂蛋白降低(OR=2.85)、高血糖(OR=2.82)、ALT增高(OR=2.80)、高尿痠血癥(OR=2.35)、HBsAg暘性(OR=1.99)、脂肪肝傢族史(OR=1.79)及常喫海產品(OR=1.58)是NAFLD的危險因素,而飲茶(OR=0.72)和經常運動(OR=0.90)則是NAFLD的保護因素. 結論 影響NAFLD髮病的因素有多種,主要是生活方式,與遺傳因素也有關.
목적 조사비주정성지방성간병(NAFLD)발병적영향인소,위예방NAFLD적발생제공가고적류행병학의거.방법 채용병례대조연구방법,대복건의과대학부속협화의원2007년1-8월체검학진적NAFLD환자385례화동기적체검건강인군825인진행조사.자제조사표수집량조일반정황、생활방식、음식습관、질병기왕사급생물화학검사결과,병대과정진행질량공제.량조간균형검험채용t검험화χ2검험;단인소분석채용χ2검험;채용비조건Logistic축보회귀분석사선변량,조출NAFLD적영향인소.결과 량조재음주량(g/주)、시부갈다、시부흡연、운동지수、진찬속도、응수빈솔、식용유충류、시부식용해산품、시부유지방간가족사급시부유고혈압,혈당증고、혈지이상、ALT증고、AST증고、고뇨산혈증、비반、고밀도지단백강저、저밀도지단백증고18개방면적차이유통계학의의(P치균＜0.05).비조건Logistic축보회귀분석결과현시,이상18개인소중유12개인소진입모형,기중비반(OR=6.35)、고혈압(OR=3.82)、혈지이상(OR=2.95)、고밀도지단백강저(OR=2.85)、고혈당(OR=2.82)、ALT증고(OR=2.80)、고뇨산혈증(OR=2.35)、HBsAg양성(OR=1.99)、지방간가족사(OR=1.79)급상흘해산품(OR=1.58)시NAFLD적위험인소,이음다(OR=0.72)화경상운동(OR=0.90)칙시NAFLD적보호인소. 결론 영향NAFLD발병적인소유다충,주요시생활방식,여유전인소야유관.
Objective To investigate the influencing factors of nonalcoholic fatty liver disease (NAFLD). Methods A hospital-based case-control study was conducted in patients with NAFLD and controls without NAFLD in a hospital from January to August in 2007. All data were analyzed by SPSS 13.0 software. Results One-way analysis of variance found that the two groups were significantly different in cigarette smoking, alcohol and tea comsumption, movement index, speed of food intake, frequency of social engagement, kinds of edible oil, marine products, family history of NAFLD, hypertension, higher blood sugar, abnormality of blood fat, higher level of ALT, higher level ofAST, hyperuricemia, obesity, decrease of high density lipoprotein (HDL), and increase of low density lipoprotein. By non-conditional logistic stepwise regression analysis, 12 of 18 factors were used to construct a model, ten of which were the risk factors and two were protective factors of NAFLD. Risk factors included obesity (OR = 6.35), hypertension(OR = 3.82),dyslipidemia (OR = 2.95), decrease of HDL (OR = 2.85), hyperglycemia (OR = 2.82), increase of ALT (OR =2.80), hyperuricemia (OR = 2.35), HBsAg positive (OR = 1.99), family history of fatty liver (OR = 1.79) and frequently intake of marine products (OR = 1.58), and protective factors included tea drinking (OR = 0.72)and exercise (OR = 0.90). Conclusions There are many influencing factors of NAFLD, and life styles are the key factors. Genetic background may also play some roles in NAFLD.
