国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
INTERNATIONAL MEDICINE & HEALTH GUIDANCE NEWS
2012年
5期
654-657
,共4页
何秀雯%吴见恨%余洽超%张碧君
何秀雯%吳見恨%餘洽超%張碧君
하수문%오견한%여흡초%장벽군
手足口病%肠道病毒%特殊表现
手足口病%腸道病毒%特殊錶現
수족구병%장도병독%특수표현
Hand,foot and mouth disease%Intestinal virus%Special appearance
目的 为手足口病的防治提供临床参考资料.方法 对本院2011年1-9月收治的手足口病患者做一回顾性分析.结果 456例中,男女比例为2.10∶1；发病年龄主要集中在1～5岁,5岁以下408例,占89.47％;发病时间4-6月份298例,占65.35％;地区分布以农村占多,有340例,占74.6％；临床特征包括疱疹,主要分布在:手足452例(99.12％),口腔粘膜406例( 89.03％)；252例伴发热(55.26％),合并肺炎有54例(11.84％),出现神经系统症状56例(7.5％),并发心肌损害的24例(5.26％)；其中发现一些特殊表现:无症状性肺炎26例(5.70％),不明显原因的指(趾)甲损害7例(1.53％).重症患儿12例(2.63％),危重病例2例(0.04％).127份标本病原学检测EV71阳性70例(55.11％),CVA16阳性43例(33.86％).本组患者按照2010年手足口病防治指南治疗,患儿预后良好,有神经系统后遗症1例,死亡病例1例.结论 本次流行高峰期为4-6月份,好发于1～5岁儿童,本次流行以EV71为主要病原体.手足口病的防治关键是掌握危重症的危险因素,严格按照2010年手足口病防治指南治疗,并在疾病早期做到早诊断,早治疗,可有效减少后遗症、降低病死率.
目的 為手足口病的防治提供臨床參攷資料.方法 對本院2011年1-9月收治的手足口病患者做一迴顧性分析.結果 456例中,男女比例為2.10∶1；髮病年齡主要集中在1～5歲,5歲以下408例,佔89.47％;髮病時間4-6月份298例,佔65.35％;地區分佈以農村佔多,有340例,佔74.6％；臨床特徵包括皰疹,主要分佈在:手足452例(99.12％),口腔粘膜406例( 89.03％)；252例伴髮熱(55.26％),閤併肺炎有54例(11.84％),齣現神經繫統癥狀56例(7.5％),併髮心肌損害的24例(5.26％)；其中髮現一些特殊錶現:無癥狀性肺炎26例(5.70％),不明顯原因的指(趾)甲損害7例(1.53％).重癥患兒12例(2.63％),危重病例2例(0.04％).127份標本病原學檢測EV71暘性70例(55.11％),CVA16暘性43例(33.86％).本組患者按照2010年手足口病防治指南治療,患兒預後良好,有神經繫統後遺癥1例,死亡病例1例.結論 本次流行高峰期為4-6月份,好髮于1～5歲兒童,本次流行以EV71為主要病原體.手足口病的防治關鍵是掌握危重癥的危險因素,嚴格按照2010年手足口病防治指南治療,併在疾病早期做到早診斷,早治療,可有效減少後遺癥、降低病死率.
목적 위수족구병적방치제공림상삼고자료.방법 대본원2011년1-9월수치적수족구병환자주일회고성분석.결과 456례중,남녀비례위2.10∶1；발병년령주요집중재1～5세,5세이하408례,점89.47％;발병시간4-6월빈298례,점65.35％;지구분포이농촌점다,유340례,점74.6％；림상특정포괄포진,주요분포재:수족452례(99.12％),구강점막406례( 89.03％)；252례반발열(55.26％),합병폐염유54례(11.84％),출현신경계통증상56례(7.5％),병발심기손해적24례(5.26％)；기중발현일사특수표현:무증상성폐염26례(5.70％),불명현원인적지(지)갑손해7례(1.53％).중증환인12례(2.63％),위중병례2례(0.04％).127빈표본병원학검측EV71양성70례(55.11％),CVA16양성43례(33.86％).본조환자안조2010년수족구병방치지남치료,환인예후량호,유신경계통후유증1례,사망병례1례.결론 본차류행고봉기위4-6월빈,호발우1～5세인동,본차류행이EV71위주요병원체.수족구병적방치관건시장악위중증적위험인소,엄격안조2010년수족구병방치지남치료,병재질병조기주도조진단,조치료,가유효감소후유증、강저병사솔.
Objective To provide clinical reference materials for hand,foot and mouth disease ( HFMD ).Methods The data on the patients with HFMD who had been hospitalized from January 2011 to September 2011 were retrospectively analyzed.Results Of 456 patients,309 were female and 147 were male,with a ratio of 2.10∶1.408 ( 89.47％ )children aged under 5; 208 ( 45.6％ )had an onset in April to June; 340 ( 74.6％ ) came from the rural areas.The clinical features included herpes,mainly distribuing on hand and food in 452 children ( 99.12％ ) and on oral mucosa in 406( 89.03％ ).252( 55.26％ ) children had fever; 54( 11.84％ ) developed pneumonia; 56( 7.5％ ) occurred nervous system symptoms; 24 ( 5.26％ ) had myocardial injury.Some special appearances were found.Asymptomatic pneumonia occurred in 26 ( 5.70％ ) children; damage to finger nail or toe nail with unknown reasons developed in 7 ( 1.53％ ).12 ( 2.63％ ) children were severe and 2 ( 0.04％ ) were in critical condition.70 of 127 ( 55.11％ ) specimens were positive with EV71 infection and 43 ( 33.86％ )were positive with CVA16 infection.The children received therapies according to the 2010 guidelines for prevention and treatment of hand, foot and mouth disease.The prognosis was fairly good.One child developed nervous system sequela and one was dead.Conclusions This prevalent peaked in April to June,most commonly occurred in children aged 1 to 5,and had the leading pathogen being EV71.The key to prevention and treatment of hand,foot and mouth disease is to identify the risk factors of critical cases,strictly abide by the 2010 guidelines for prevention and treatment of hand,foot and mouth disease,and confirm diagnosis and administer treatment as early as possible in the early stage of the disease,which can effectively reduce sequela and mortality.
