CAJ | 학술논문

目的　探讨原发性高血压(EH)、动脉粥样硬化性血栓性脑梗死(ABI)及腔隙性脑梗死(LS)患者HLA-DQA1 位点的基因分型及其遗传易感性。方法　采用PCR-SSP方法对EH、ABI 及LS共155例患者和正常对照64人进行HLA-DQA1位点的基因分型和遗传易感性分析。结果　EH、ABI 及LS组的HLA-DQA1*0301基因频率均明显高于正常对照组，分别为33.653 8对17.968 8，36.585 4对17.968 8，33.064 5对17.968 8（P<0.01）,而HLA-DQA1*0103基因频率却明显低于正常对照组(P<0.05或P<0.01) 。结论　HLA-DQA1*0301等位基因可能与EH、ABI 及LS的遗传易感性相关,而HLA-DQA1*0103等位基因可能与其保护性相关。
목적　탐토원발성고혈압(EH)、동맥죽양경화성혈전성뇌경사(ABI)급강극성뇌경사(LS)환자HLA-DQA1 위점적기인분형급기유전역감성。방법　채용PCR-SSP방법대EH、ABI 급LS공155례환자화정상대조64인진행HLA-DQA1위점적기인분형화유전역감성분석。결과　EH、ABI 급LS조적HLA-DQA1*0301기인빈솔균명현고우정상대조조，분별위33.653 8대17.968 8，36.585 4대17.968 8，33.064 5대17.968 8（P<0.01）,이HLA-DQA1*0103기인빈솔각명현저우정상대조조(P<0.05혹P<0.01) 。결론　HLA-DQA1*0301등위기인가능여EH、ABI 급LS적유전역감성상관,이HLA-DQA1*0103등위기인가능여기보호성상관。
Objective　To study the types of HLA-DQA1 alleles in patients with essential hypertension (EH), athrothrombotic brain infarction (ABI) and lacunar stroke (LS) and normal control individuals and the hereditary susceptibility of HLA-DQA1 alleles to those diseases. Methods　The allelic typing of HLA--DQA1 was detected by PCR-SSP in 155 cases of EH, ABI and LS and 64 normal individuals. Results　The frequencies of HLA-DQA1*0301 in EH, ABI and LS groups were obviously higher than that in normal control group (33.6538 vs. 17.9688, 36.5884 vs. 17.9688, 33.0645 vs. 17.9688, P<0.01) .The frequencies of HLA-DQA1*0103 in groups of EH, ABI, LS, ABI with EH, and LS with EH were lower than that in the normal control group （6.7308 vs17.1875，RR=0.3916 ，P<0.01；6.0976 vs. 17.1875，RR=0.3548 ，P<0.05；6.4566 vs17.1875，RR=0.3754 ，P<0.01；2.3809 vs17.1875，RR=0.1385 ，P<0.01；3.5714 vs. 17.1875，RR=0.2078 ，P<0.01. Conclusion　HLA-DQA1*0301 allele may be a correlative gene with hereditary susceptibility of EH, ABI and LS, and HLA- DQA1*0103 allele may be a protective gene of those diseases.