CAJ | 학술논문

目的　探讨表皮生长因子(hEGF)在慢性肾小球肾炎(CGN)肾小管间质病变中的作用。方法　采用放射免疫分析法检测36例CGN患者及13例正常人血清、尿和肾活检组织hEGF的含量。结果　CGN患者肾组织和尿hEGF含量均显著高于对照组，且肾小管间质病变愈严重，肾组织hEGF含量愈高；尿hEGF含量与肾组织hEGF含量呈高度正相关。结论　hEGF在CGN肾小管间质损伤过程中可能具有重要作用，尿hEGF含量检测可反映肾局部hEGF含量变化。
목적　탐토표피생장인자(hEGF)재만성신소구신염(CGN)신소관간질병변중적작용。방법　채용방사면역분석법검측36례CGN환자급13례정상인혈청、뇨화신활검조직hEGF적함량。결과　CGN환자신조직화뇨hEGF함량균현저고우대조조，차신소관간질병변유엄중，신조직hEGF함량유고；뇨hEGF함량여신조직hEGF함량정고도정상관。결론　hEGF재CGN신소관간질손상과정중가능구유중요작용，뇨hEGF함량검측가반영신국부hEGF함량변화。
Objective　To study the effect of human epidermal growth factor (hEGF) on tubulointerstitial lesions in patients with chronic glomerulnephritis (CGN).Methods　The levels of HEGF in serum, urine and renal biopsy tissues in 36 patients were detected by RIA and compared with 13 normal controls.Results　The hEGF levels in patients'renal tissues and urine were sighificantly higher than those in normal controls,and the distribution was correlated with the extent of tubulointerstitial lesions. There was significantly positive correlation between urinary and renal HEGF level.Conclusion　HEGF is probably involved in tubulinterstitial lesions in patients with CGN and urinary HEGF level may reflect change of renal HEGF level.