北京大学学报（医学版）
北京大學學報（醫學版）
북경대학학보（의학판）
JOURNAL OF BEIJING MEDICAL UNIVERSITY(HEALTH SCIENCES)
2009年
4期
456-458
,共3页
田增民%陈涛%Nanbert ZHONG%李志超%尹丰%刘爽
田增民%陳濤%Nanbert ZHONG%李誌超%尹豐%劉爽
전증민%진도%Nanbert ZHONG%리지초%윤봉%류상
橄榄体桥脑小脑萎缩%干细胞移植%治疗结果
橄欖體橋腦小腦萎縮%榦細胞移植%治療結果
감람체교뇌소뇌위축%간세포이식%치료결과
Olivopontocerebellar atrophies%Stem cell transplantation%Treatment outcomes
Objective:To study the clinical effect of neural stem cell transplantation in the treatment of inherited cerebellar atrophy (CA). Methods: The cells from human fetal cerebellum (8-10 weeks of gestation) were grown and expanded in vitro. The cultured neurospheres were then implanted into the dentate nuclei of patients by stereo tactic operation. Totally, 12 patients (7 males and 5 females with age ranging 22-62 years, mean 43 years) were treated by this operation from August 2006 to August 2008. Results: The cells of fetal cerebellum were expanded by 107folds in undifferentiated state in the culture. After the operation, no rejection was detected. Follow up, the effective rates were 58. 3% after 3 months, 75.0% after 6 months, and 66.7% for 12-24 months (mean 18 months). Conclusion: the transplantation of in vitro cultured neural stem cell is a feasible and effective treatment for inherited CA, but the long term effectiveness need to be taken in consideration.
