CAJ | 학술논문

目的：探讨无创正压通气与纳洛酮联合治疗Ⅱ型呼吸衰竭并发肺性脑病的临床疗效。方法：56例患者随机分为2组，对照组28例给予常规药物治疗。治疗组28例在对照组的基础上加用无创正压通气同时加用纳洛酮0．4～0．8mg静脉推注，2次／d；2d为1疗程，共3个疗程，观察治疗前、后患者的临床表现、血气分析的变化。结果：2组比较，治疗组总有效率92．9%，对照组64．3％，差异有统计学意义（P〈0．05）。治疗后治疗组PaO2、SpO2显著高于对照组（P〈0．01），PaCO2显著低于对照纽（P〈0．01）。结论：无创正压通气与纳洛酮联用较单纯药物治疗能明显改善缺氧及二氧化碳潴留，更好的缓解临床症状。
목적：탐토무창정압통기여납락동연합치료Ⅱ형호흡쇠갈병발폐성뇌병적림상료효。방법：56례환자수궤분위2조，대조조28례급여상규약물치료。치료조28례재대조조적기출상가용무창정압통기동시가용납락동0．4～0．8mg정맥추주，2차／d；2d위1료정，공3개료정，관찰치료전、후환자적림상표현、혈기분석적변화。결과：2조비교，치료조총유효솔92．9%，대조조64．3％，차이유통계학의의（P〈0．05）。치료후치료조PaO2、SpO2현저고우대조조（P〈0．01），PaCO2현저저우대조뉴（P〈0．01）。결론：무창정압통기여납락동련용교단순약물치료능명현개선결양급이양화탄저류，경호적완해림상증상。
Objective： To explore the therapeutic effect of noninvasive positive ventilation plus Naloxone in treatment of type II respiratory failure complicated with pulmonary encephalopathy. Methods： Fifty-six patients were randomly divided into 2 groups. Twenty-eight cases in control group received conventional medical therapy, and 28 cases in treatment group received noninvasive positive ventilation puls Naloxone 0. 4-0. 8 mg intrave nously based on the conventional therapy. Clinical manifestations and changes of arterial blood gas were observed before and after treatment. Results： The total efficacy rate of treatment group vs control group were 92. 9% vs 64. 3%, there was a significant difference among the two groups （P〈0. 05）. PaO2 and SpO2 were significantly higher after treatment in treatment group than those in control group, and PaCO2 was significantly lower in con trol group （P〈0. 01）. Conclusions： Combined use of noninvasive ventilation puls Naloxone can rapidly improve clinical symptoms and arterial blood gases.