CAJ | 학술논문

早期诊断是肿瘤研究的重要方向之一.虽然在宫颈癌、乳腺癌等一些肿瘤中建立了早期筛查方法,但对于大部分肿瘤而言,尚没有敏感、特异的早期诊断方法.高通量分子生物学技术的建立,使研究者可以在全基因组、转录组、蛋白质组等水平筛选分子标志物,大大提高了筛选效率.已有研究筛选出了大量的肿瘤早期分子改变和候选早期分子标志物,未来将有更多敏感、特异的早期诊断分子标志物被发现并用于肿瘤早期筛查和诊断.
조기진단시종류연구적중요방향지일.수연재궁경암、유선암등일사종류중건립료조기사사방법,단대우대부분종류이언,상몰유민감、특이적조기진단방법.고통량분자생물학기술적건립,사연구자가이재전기인조、전록조、단백질조등수평사선분자표지물,대대제고료사선효솔.이유연구사선출료대량적종류조기분자개변화후선조기분자표지물,미래장유경다민감、특이적조기진단분자표지물피발현병용우종류조기사사화진단.
Early detection is the important area of cahcer research.Although many early screening methods of cervical carcinoma and breast carcinoma have been established.no sensitive and specific methods can be used in clinical practice for most kinds of cancer.High throughput molecular technology enables re-searchers to screen candidate biomarker in genome or transcriptome or proteome level.Recent studv has i-dentified a lot of early molecular changes and candidate biomarkers for early diagnosis.and more sensitive and specific biomarkers will be found and used in clinical practice in the future.