CAJ | 학술논문

目的探讨血清免疫球蛋白IgM和C反应蛋白(CRP)联合测定在诊断新生儿早期感染性疾病中的诊断价值.方法采刚免疫比浊法测定206例发生感染性疾病的新生儿(感染组)、146例非感染病症新生儿(未感染组)的血清IgM和CRP水平.结果感染组CRP水平与非感染组比较,差异无显著性(P＞0.05);感染组IgM水平与非感染组比较,差异有显著性(P＜0.05).CRP对感染性疾病的诊断灵敏度Se为96.12%,特异度Sp为41.78%,准确度Ac为73.60%;IgM对感染性疾病的诊断灵敏度Se为88.29%,特异度SP为91.78%,准确度为Ac89.49%;两者联合测定,灵敏度SeCs为84.86%,特异度SpCs为95.21%.结论血清IgM与CRP联合测定可作为诊断新生儿早期感染性疾病的指标.
목적 탐토혈청면역구단백IgM화C반응단백(CRP)연합측정재진단신생인조기감염성질병중적진단개치.방법 채강면역비탁법측정206례발생감염성질병적신생인(감염조)、146례비감염병증신생인(미감염조)적혈청IgM화CRP수평.결과 감염조CRP수평여비감염조비교,차이무현저성(P＞0.05);감염조IgM수평여비감염조비교,차이유현저성(P＜0.05).CRP대감염성질병적진단령민도Se위96.12%,특이도Sp위41.78%,준학도Ac위73.60%;IgM대감염성질병적진단령민도Se위88.29%,특이도SP위91.78%,준학도위Ac89.49%;량자연합측정,령민도SeCs위84.86%,특이도SpCs위95.21%.결론 혈청IgM여CRP연합측정가작위진단신생인조기감염성질병적지표.
Objective To explore the diagnostic value of combinatin detection of serum immunoglobin M (IgM) and C-reactive protein (CRP) for neonatal infectious diseases at the early stage.Methods Immunoturbidimetry was used to detect the serurn levels of IgM and CRP in 206 neonates with infectious diseases (infection group) and 146 with non-infectious diseases (non-infection group). Results There was no significant difference in CRP level between infection group and non-infection group (P＞0.05);whereas IgM level differed significantly between the two groups (P＜0.05). The sensitivity of CRP for infectious diseases was 96.12%, the specificity was 41.78%, and the accuracy was 73.60%; while the sensitivity ofIgM for infectious diseases was 88.29%, the specificity was 91.78% and the accuracy diseases was 89.49%. The sensitivity of combination detection was 84.86% and the specificity was 95.21%. Conclusions Combination detectinon of serum IgM and CRP can be used as an indicator for the early diagnosis of neonatal infectious diseases.diseases in newbrons.