CAJ | 학술논문

目的研究拉米夫定联合柴胡总皂苷在体内抗乙型肝炎病毒(HBV)的作用.方法采用乙型肝炎动物模型,用拉米夫定联合柴胡总皂苷(联合组)口服治疗28 d,停药观察7 d,并与单用拉米夫定(拉米组)、柴胡总皂苷(柴胡组)作为对照,检测用药前后血清中HBV DNA、HBsAg及血清转氨酶(ALT、AST).结果联合组用药后能显著降低血清中HBV DNA及HBsAg水平(P<0.05),停药7 d后HBV DNA及HBsAg含量较用药28 d时无明显"反跳"(P＞0.05),拉米组与柴胡组停药7 d后有明显回升(P<0.05).各组用药28 d及停药7 d后ALT及AST含量同一时相内未有明显变化(P＞0.05).结论拉米夫定联合柴胡总皂苷用药后在体内有抗乙型肝炎病毒的作用,抗病毒效果稳定持久.
목적 연구랍미부정연합시호총조감재체내항을형간염병독(HBV)적작용.방법 채용을형간염동물모형,용랍미부정연합시호총조감(연합조)구복치료28 d,정약관찰7 d,병여단용랍미부정(랍미조)、시호총조감(시호조)작위대조,검측용약전후혈청중HBV DNA、HBsAg급혈청전안매(ALT、AST).결과 연합조용약후능현저강저혈청중HBV DNA급HBsAg수평(P<0.05),정약7 d후HBV DNA급HBsAg함량교용약28 d시무명현"반도"(P＞0.05),랍미조여시호조정약7 d후유명현회승(P<0.05).각조용약28 d급정약7 d후ALT급AST함량동일시상내미유명현변화(P＞0.05).결론 랍미부정연합시호총조감용약후재체내유항을형간염병독적작용,항병독효과은정지구.
Objective To study the effect of anti-hepatitis B virus of Lamivudine combined with Saikosaponins in vivo. Methods Chongqing duck hepatitis B model was selected and given to Lamivudine combined with Saikosaponins(combined group) oral treatment 28d, then the ducks were observed 7d after drug withdrawal. The levels of serum HBV DNA, HBsAg and transaminase(ALT, AST) were detected before and after treatment, and compared with that in Lamivudine group and Saikosaponins group as control. Results In combined group,the levels of serum HBV DNA and HbsAg were significantly decreased(P ＜ 0.05), and 7d after drug withdrawal the levels of serum HBV DNA and HBsAg showed no" anti-jump" compared with that at drug treatment 28d(P ＞ 0.05). In Lamivudine group and Saikosaponins group the levels of those increased again 7d after drug withdrawal (P ＜ 0. 05). In each group the levels of serum ALT and AST did not change within the same phase during drug treatment 28d and 7d after drug withdrawal(P ＞ 0. 05). Conclusion Lamivudine combined with Saikosaponins in vivo had the effect of anti-hepatitis Bvirus, and the effect was stable and lasting.