CAJ | 학술논문

目的对比分析三阴性乳腺癌和三阳性乳腺癌患者的乳腺x线摄影表现.方法回顾性分析631例经手术病理证实的女性原发性乳腺癌患者资料,其中三阴性乳腺癌117例,三阳性乳腺癌44例,术前全部患者完成双侧乳腺X线常规摄影.分析三阴性和三阳性乳腺癌的X线表现特征,并采用x2检验比较二者的肿块和钙化发生率、病理组织学类型；采用独立样本t检验比较患者的年龄和肿块大小.结果三阴性和三阳性乳腺癌在X线摄影中病变的可见率分别为88.0％(103/117)和90.9％(40/44),差异无统计学意义(x2=0.055,P＞0.05).三阴性乳腺癌(56/103)比三阳性乳腺癌(12/40)更多表现为单纯肿块(x2=6.860,P＜ 0.01),较少表现为钙化(分别为37/103和24/40,x2=7.423,P＜0.01).三阴性和三阳性乳腺癌患者的肿块直径分别为(2.6±1.4)和(2.0±0.6) cm,差异有统计学意义(t=2.087,P＜0.05).三阴性和三阴性乳腺癌患者的平均年龄分别为(52±9)和(48±8)岁,差异有统计学意义(t=2.759,P＜0.01).三阴性和三阳性乳腺癌的病理组织类型均以浸润性导管癌为主,其中基底样型占三阴性乳腺癌的48.7％(57/117),三阳性乳腺癌中未见此亚型表达.结论 X线摄影片上显示为单纯的肿块、平均直径较大、较少伴有钙化等特点有助于三阴性乳腺癌的X线诊断.
목적 대비분석삼음성유선암화삼양성유선암환자적유선x선섭영표현.방법 회고성분석631례경수술병리증실적녀성원발성유선암환자자료,기중삼음성유선암117례,삼양성유선암44례,술전전부환자완성쌍측유선X선상규섭영.분석삼음성화삼양성유선암적X선표현특정,병채용x2검험비교이자적종괴화개화발생솔、병리조직학류형；채용독립양본t검험비교환자적년령화종괴대소.결과 삼음성화삼양성유선암재X선섭영중병변적가견솔분별위88.0％(103/117)화90.9％(40/44),차이무통계학의의(x2=0.055,P＞0.05).삼음성유선암(56/103)비삼양성유선암(12/40)경다표현위단순종괴(x2=6.860,P＜ 0.01),교소표현위개화(분별위37/103화24/40,x2=7.423,P＜0.01).삼음성화삼양성유선암환자적종괴직경분별위(2.6±1.4)화(2.0±0.6) cm,차이유통계학의의(t=2.087,P＜0.05).삼음성화삼음성유선암환자적평균년령분별위(52±9)화(48±8)세,차이유통계학의의(t=2.759,P＜0.01).삼음성화삼양성유선암적병리조직류형균이침윤성도관암위주,기중기저양형점삼음성유선암적48.7％(57/117),삼양성유선암중미견차아형표체.결론 X선섭영편상현시위단순적종괴、평균직경교대、교소반유개화등특점유조우삼음성유선암적X선진단.
Objective To analyze the mammographic findings of triple-negative breast cancer [TNBC,which is estrogen receptor (ER) negative,progesterone receptor (PR) negative,and human epidermal growth factor receptor 2 ( HER2 ) negative ] and triple-positive breast cancer ( TPBC,which is ER positive,PR positive,and HER2 positive ),and to evaluate the relationship of immunohistochemologic receptor status and mammographic findings.Methods The immunohistochemistry results of 631 cases with breast cancers were reviewed,including 117 cases of TNBC and 44 cases of TPBC.All of the patients took mammography at initial diagnosis.We retrospectively evaluated the visibility,morphology,distribution and size of the lesion (masses and calcifications) and breast density on mammography of TNBC,and compared them with those of TPBC.The age onset and tumor sizes of TNBC and TPBC were compared by using Chi-square test and t test.Results The visibility rate of TNBC and TPBC on mammography were 88.0％(103/117) and 90.9％ (40/44),and the difference between them was insignificant ( x2 =0.055,P ＞0.05).TNBC was more frequently associated with merely a mass (56/103) than TPBC (12/40) (x2 =6.860,P＜0.01 ),and the mean diameter of the mass of TNBC [ ( 2.6 ± 1.4 ) cm ] was larger than that of TPBC [(2.0 ± 0.6) cm] (t =2.087,P ＜ 0.05). TNBC were less frequently associated with microcalcifications (37/103) than TPBC ( 24/40 ) ( x2 =7.423,P ＜ 0.01 ).Mammographic density and lesion visibility were similar between the two different immunophenotypes of breast cancers.The mean age of TNBC (52±9) was more than that of TPBC (48 ±8) (t =2.759,P ＜0.01).Infiltrating ductal carcinoma was the main pathologic type of both groups.Basal-like breast cancer accounted for 49％ (57/117 ) of TNBC while none happened in TPBC.Conclusions TNBC shows merely a mass with indistinct margins,lager size and is less associated with microcalcifications.These mammographic features might be useful in diagnosing triple negative breast cancer.