CAJ | 학술논문

目的探讨18F-氟乙酸盐(FAC)及其前体化合物2-甲磺酸基乙酸乙酯(EOMG)的合成和进行质量分析.方法改进前体化合物EOMG的合成方法,利用HPLC法测定该前体化合物的化学纯度,并通过各种光谱学手段对其结构进行鉴定.以EOMG为前体,用Explora GN模块合成18F-FAC,再用ExploraLC除去其中的化学杂质,HPLC法和放射性薄层色谱(TLC)法检测其放化纯、化学纯度和比活度.结果合成并鉴定了前体化合物EOMG,产率为70%,化学纯度为97.0%(按色谱峰面积计算).合成了18F-FAC,放化纯＞98%,且无明显的化学杂质,比活度为236.5 MBq/μmol.结论该研究为制备有效、质量可控的18F-FAC提供了依据.
목적 탐토18F-불을산염(FAC)급기전체화합물2-갑광산기을산을지(EOMG)적합성화진행질량분석.방법 개진전체화합물EOMG적합성방법,이용HPLC법측정해전체화합물적화학순도,병통과각충광보학수단대기결구진행감정.이EOMG위전체,용Explora GN모괴합성18F-FAC,재용ExploraLC제거기중적화학잡질,HPLC법화방사성박층색보(TLC)법검측기방화순、화학순도화비활도.결과 합성병감정료전체화합물EOMG,산솔위70%,화학순도위97.0%(안색보봉면적계산).합성료18F-FAC,방화순＞98%,차무명현적화학잡질,비활도위236.5 MBq/μmol.결론 해연구위제비유효、질량가공적18F-FAC제공료의거.
Objective To synthesize and analyze sodium 18F-fluoroacetate (FAC) and its precursor ethyl O-mesylglycolate (EOMG). Methods EOMG was synthesized using modified method. Its chemical purity was checked by HPLC and its structure was elucidated on the basis of spectral analyses. Final product of 18F-FAC was synthesized based on general nucleophilic reactions module Explora GN using EOMG as a precursor. Liquid chromatography Explora LC was applied to get rid of its chemical impurities.Then HPLC and radio-thin layer chromatography were used to assay its radiochemical purity, chemical purity and specific activity. Results EOMG was synthesized and identified. Its yield was 70% and its chemical purity was 97.0% (calculated by chromatographic peak area). The radiochemical purity of 18F-FAC was more than 98%, and its specific activity was 236. 5 MBq/μmol. Conclusion This synthetic method for 18F-FAC and its precursor can be defined as effective and highly quality-controlled.