CAJ | 학술논문

目的：观察肾移植术后受者T、B淋巴细胞及红细胞活性的变化并探讨其关系。方法：测定41例肾移植受者T、B淋巴细胞增殖反应及红细胞C3b受体花环形成率(C3bRR)。结果：T淋巴细胞增殖反应在术后1～3周明显增强，7～8周减弱；B淋巴细胞增殖反应在术后6～8周明显增强；急性排斥期间，T淋巴细胞增殖活性增强，未观察到B淋巴细胞增殖反应和红细胞C3b受体活性的明显改变。术后红细胞活性逐渐增强，与血红蛋白的变化呈正相关，与淋巴细胞活性无明显相关关系。结论：术后早期T淋巴细胞活性增强与移植物的刺激有关；动态观察T淋巴细胞增殖反应有助于急性排斥反应的诊断。术后B淋巴细胞活性逐渐增强的意义尚待阐明。红细胞活性测定是否可作为移植后免疫监测指标尚需进一步探讨。
목적：관찰신이식술후수자T、B림파세포급홍세포활성적변화병탐토기관계。방법：측정41례신이식수자T、B림파세포증식반응급홍세포C3b수체화배형성솔(C3bRR)。결과：T림파세포증식반응재술후1～3주명현증강，7～8주감약；B림파세포증식반응재술후6～8주명현증강；급성배척기간，T림파세포증식활성증강，미관찰도B림파세포증식반응화홍세포C3b수체활성적명현개변。술후홍세포활성축점증강，여혈홍단백적변화정정상관，여림파세포활성무명현상관관계。결론：술후조기T림파세포활성증강여이식물적자격유관；동태관찰T림파세포증식반응유조우급성배척반응적진단。술후B림파세포활성축점증강적의의상대천명。홍세포활성측정시부가작위이식후면역감측지표상수진일보탐토。
Aim:To investigate immune activity of T/B lymphocytes and erythrocytes in renal transplant recipients. Methods:Tne T/B lymphocyte proliferation and red blood cell C3b receptor rate (C3bRR) were determined in 41 cases of renal transplant re-cipients. Results:After renal transplantation,T cell proliferation was enhanced from first to third week and was inhibited from 7th to8th week,B cell proliferation was enhanced from 5th to 8th week. During the period of acute rejection, T lymphocyte proliferationwas promoted. Meanwhile B cell proliferation and RBC-C3bRR were not markedly changed. Conclusion:The promotion of T lym-phocyte activity during the early period of post-operation may be related to the stimulation of allograft. Dynamic examination of Tcell proliferation is helpful to the diagnosis of acute rejection. The mechanisms of the promotion of B cell activity are not clear. It isnot of significance to evaluate the renal transplant recipients' immune function by examining RBC-C3bRR.