CAJ | 학술논문

植入式高分子医用材料表面会粘附细菌形成生物膜引发生物材料相关的感染(BRI),给高分子医用材料的广泛应用提出了重大挑战.本文从BRI发生的机制入手,综述了通过高分子医用材料表面改性减少细菌粘附与使用抗菌素-生物材料体系两个方面来抵抗BRI发生的研究进展,重点阐述了局部抗菌药物缓释体系及纳米技术在抗菌药物缓释体系中的应用,并指出高分子前药控释体系的研究和应用是抗高分子医用材料感染的发展趋势.
식입식고분자의용재료표면회점부세균형성생물막인발생물재료상관적감염(BRI),급고분자의용재료적엄범응용제출료중대도전.본문종BRI발생적궤제입수,종술료통과고분자의용재료표면개성감소세균점부여사용항균소-생물재료체계량개방면래저항BRI발생적연구진전,중점천술료국부항균약물완석체계급납미기술재항균약물완석체계중적응용,병지출고분자전약공석체계적연구화응용시항고분자의용재료감염적발전추세.
The surface of polymer medical material implants adsorbs bacteria to form biofilm lead to biomaterial related infection (BRI) represent a significant challenge to the application of polymer medical material.This paper introduced BRI mechanism,summarized the research of surface modification to reduce bacterial adhesion and antibacterial- biomaterial system.The recent advances of these two methods resistant the occurrence of BRI.Emphasize on local antibacterial sustained- release system and the application of nanotechnology in antibacterial sustained- release system.The research and application of polymer prodrug controlled-release system is the tendency of anti-infective polymer medical material.