中国小儿急救医学
中國小兒急救醫學
중국소인급구의학
CHINESE PEDIATRIC EMERGENCY MEDICINE
2012年
2期
166-167
,共2页
传染性单核细胞增多症%T细胞亚群%CD4/CD8%儿童
傳染性單覈細胞增多癥%T細胞亞群%CD4/CD8%兒童
전염성단핵세포증다증%T세포아군%CD4/CD8%인동
infectious mononucleosis%T-lymphocyte subgroup%CD4/CD8%Children
目的 探讨传染性单核细胞增多症(infectious mononucleosis,IM)患儿T细胞亚群的变化.方法 选取2005年1月至2010年12月在我院住院确诊为Epstein-Barr( EB)病毒感染引起的IM患儿60例为IM组,同期来我院门诊健康体检患儿36例为对照组.所有患儿行血常规、血涂片、T细胞亚群、肝肾功能及病毒抗体、肝炎病毒抗体检测.T细胞亚群检测包括CD3、CD4、CD8、CD4/CD8.结果 与对照组比较,IM组患儿CD3( 81.55％±9.04％)、CD8 (58.13％±13.35％)比例较对照组(53.58％±5.97％)、(31.22％±8.72％)明显升高(P＜0.05)；CD4( 18.19％±7.61％)、CD4/CD8(0.37±0.33)比值较对照组(36.98％±5.32％、1.98±0.41)明显降低(P＜0.05).IM组患儿白细胞计数、异型淋巴细胞比值及谷丙转氨酶与CD4/CD8的下降无相关性(P均＞0.05).结论 EB病毒感染引起IM患儿免疫功能显著低下,可早期进行免疫干预治疗.
目的 探討傳染性單覈細胞增多癥(infectious mononucleosis,IM)患兒T細胞亞群的變化.方法 選取2005年1月至2010年12月在我院住院確診為Epstein-Barr( EB)病毒感染引起的IM患兒60例為IM組,同期來我院門診健康體檢患兒36例為對照組.所有患兒行血常規、血塗片、T細胞亞群、肝腎功能及病毒抗體、肝炎病毒抗體檢測.T細胞亞群檢測包括CD3、CD4、CD8、CD4/CD8.結果 與對照組比較,IM組患兒CD3( 81.55％±9.04％)、CD8 (58.13％±13.35％)比例較對照組(53.58％±5.97％)、(31.22％±8.72％)明顯升高(P＜0.05)；CD4( 18.19％±7.61％)、CD4/CD8(0.37±0.33)比值較對照組(36.98％±5.32％、1.98±0.41)明顯降低(P＜0.05).IM組患兒白細胞計數、異型淋巴細胞比值及穀丙轉氨酶與CD4/CD8的下降無相關性(P均＞0.05).結論 EB病毒感染引起IM患兒免疫功能顯著低下,可早期進行免疫榦預治療.
목적 탐토전염성단핵세포증다증(infectious mononucleosis,IM)환인T세포아군적변화.방법 선취2005년1월지2010년12월재아원주원학진위Epstein-Barr( EB)병독감염인기적IM환인60례위IM조,동기래아원문진건강체검환인36례위대조조.소유환인행혈상규、혈도편、T세포아군、간신공능급병독항체、간염병독항체검측.T세포아군검측포괄CD3、CD4、CD8、CD4/CD8.결과 여대조조비교,IM조환인CD3( 81.55％±9.04％)、CD8 (58.13％±13.35％)비례교대조조(53.58％±5.97％)、(31.22％±8.72％)명현승고(P＜0.05)；CD4( 18.19％±7.61％)、CD4/CD8(0.37±0.33)비치교대조조(36.98％±5.32％、1.98±0.41)명현강저(P＜0.05).IM조환인백세포계수、이형림파세포비치급곡병전안매여CD4/CD8적하강무상관성(P균＞0.05).결론 EB병독감염인기IM환인면역공능현저저하,가조기진행면역간예치료.
Objective To investigate the change of T-lymphocyte subgroup in children with infectious mononucleosis (IM).Methods Sixty young children with IM caused by Epstein-Barr virus (EBV) were recruited for this study in Jiaxing First Hospital from Jan 2005 to Dec 2010.Thirty-six normal children were chosen as control group.Both of the two groups were detected blood test,blood smear,T-lymphocyte subgroup ( including CD3,CD4,CD8,CD4/CD8 ),liver and kidney function test,IgM antibodies of EBV,cytomegalovirus,adenovirus,and hepatitis virus.Results Compared with the control group (53.58％ ± 5.97％,31.22％±8.72％ ),the ratio of CD3 (81.55％ ±9.04％ ) and CD8(58.13％ ± 13.35％ ) were significantly higher in IM group( P ＜0.05 ).And the ratio of CD4 ( 18.19％ ± 7.61％ ) and CD4/CD8 (0.37 ± 0.33) were significantly lower in IM group,compared with the control group (36.98％ ± 5.32％,1.98 ± 0.41 )(P ＜ 0.05 ).While the leukocyte count,the ratio of abnormal leukomonocyte,and alanine transaminase had no correlation with the decrease of CD4/CD8 ( P ＞ 0.05 ).Conclusion Children with IM caused by EBV have bad immunocompetence,and we can treat them with immunotherapy early.
