国际中医中药杂志
國際中醫中藥雜誌
국제중의중약잡지
INTERNATIONAL JOURNAL OF TRIDITIONAL CHINESE MEDICINE
2012年
10期
886-887
,共2页
大柴胡汤%急性胰腺炎%炎性因子
大柴鬍湯%急性胰腺炎%炎性因子
대시호탕%급성이선염%염성인자
Dachaihu decoction%Acute pancreatitis%Plasma inflammatory cytokines
目的 观察大柴胡汤灌肠对急性胰腺炎患者血浆炎性因子的影响.方法 收集2009年1月至2011年12月潍坊市益都中心医院急诊科186例急性胰腺炎患者,按随机数字表法分为中药组94例和对照组92例,对照组给予西医常规治疗,中药组在西医常规治疗的基础上给予大柴胡汤灌肠,2次/d连续7d.分别于第2、5、7天检测两组患者的肿瘤坏死因子α(TNF-α)、白细胞介素1β (IL-1β)、白细胞介素6 (IL-6)水平.结果 治疗第2、5、7天中药组患者的TNF-α为[(42.18±20.57) mg/L、(22.06±10.73) mg/L、(9.88±4.62) mg/L],IL-1β为[(0.28±0.11)μg/L、(0.19±0.02) μg/L、(0.18±0.06) μg/L],IL-6[ (87.90±49.41)ng/L、(16.59±10.24) ng/L、(14.96±11.42) ng/L],均低于对照组治疗第2、5、7天[TNF-α分别为(53.18±20.53) mg/L、(43.78±11.08) mg/L、(19.69± 11.53) mg/L; IL-1β分别为(0.31±0.04) μg/L、(0.25±0.12)μg/L、(0.22±0.07) μg/L; IL-6分别为(96.43±31.48) ng/L、(51.63±37.16) ng/L、(44.36±27.54) ng/L,P均＜0.05]的水平.结论 大柴胡汤灌肠有助于降低急性胰腺炎患者血浆炎性因子水平.
目的 觀察大柴鬍湯灌腸對急性胰腺炎患者血漿炎性因子的影響.方法 收集2009年1月至2011年12月濰坊市益都中心醫院急診科186例急性胰腺炎患者,按隨機數字錶法分為中藥組94例和對照組92例,對照組給予西醫常規治療,中藥組在西醫常規治療的基礎上給予大柴鬍湯灌腸,2次/d連續7d.分彆于第2、5、7天檢測兩組患者的腫瘤壞死因子α(TNF-α)、白細胞介素1β (IL-1β)、白細胞介素6 (IL-6)水平.結果 治療第2、5、7天中藥組患者的TNF-α為[(42.18±20.57) mg/L、(22.06±10.73) mg/L、(9.88±4.62) mg/L],IL-1β為[(0.28±0.11)μg/L、(0.19±0.02) μg/L、(0.18±0.06) μg/L],IL-6[ (87.90±49.41)ng/L、(16.59±10.24) ng/L、(14.96±11.42) ng/L],均低于對照組治療第2、5、7天[TNF-α分彆為(53.18±20.53) mg/L、(43.78±11.08) mg/L、(19.69± 11.53) mg/L; IL-1β分彆為(0.31±0.04) μg/L、(0.25±0.12)μg/L、(0.22±0.07) μg/L; IL-6分彆為(96.43±31.48) ng/L、(51.63±37.16) ng/L、(44.36±27.54) ng/L,P均＜0.05]的水平.結論 大柴鬍湯灌腸有助于降低急性胰腺炎患者血漿炎性因子水平.
목적 관찰대시호탕관장대급성이선염환자혈장염성인자적영향.방법 수집2009년1월지2011년12월유방시익도중심의원급진과186례급성이선염환자,안수궤수자표법분위중약조94례화대조조92례,대조조급여서의상규치료,중약조재서의상규치료적기출상급여대시호탕관장,2차/d련속7d.분별우제2、5、7천검측량조환자적종류배사인자α(TNF-α)、백세포개소1β (IL-1β)、백세포개소6 (IL-6)수평.결과 치료제2、5、7천중약조환자적TNF-α위[(42.18±20.57) mg/L、(22.06±10.73) mg/L、(9.88±4.62) mg/L],IL-1β위[(0.28±0.11)μg/L、(0.19±0.02) μg/L、(0.18±0.06) μg/L],IL-6[ (87.90±49.41)ng/L、(16.59±10.24) ng/L、(14.96±11.42) ng/L],균저우대조조치료제2、5、7천[TNF-α분별위(53.18±20.53) mg/L、(43.78±11.08) mg/L、(19.69± 11.53) mg/L; IL-1β분별위(0.31±0.04) μg/L、(0.25±0.12)μg/L、(0.22±0.07) μg/L; IL-6분별위(96.43±31.48) ng/L、(51.63±37.16) ng/L、(44.36±27.54) ng/L,P균＜0.05]적수평.결론 대시호탕관장유조우강저급성이선염환자혈장염성인자수평.
Objective To observe effect of Dachaihu decoction on plasma inflammatory cytokines of acute pancreatitis patients.Methods 186 cases of acute pancreatitis were randomly recruited into TCM group and control group.The control group was given routine treatment.On the basis of the control group,the TCM group was given Dachaihu decoction for enema additionally,twice daily,7 days.Then plasma inflammatory cytokines level was tested in both groups.Results TCM group had lower levels of TNF-α [ (42.18 ± 20.57) mg/L、(22.06± 10.73) mg/L,(9.88 ±4.62)mg/L],IL-1β[ (0.28 ±0.11) μg/L,(0.19±0.02) μg/L,(0.18 ±0.06)μg/L],and IL-6[(87.90±49.41)ng/L,(16.59±10.24) ng/L,(14.96±11.42) ng/L] at 2/5/7 days than the control group.There were statistical difference (P＜0.05).Conclusion Enema with Dachaihu decoction was effective on reducing plasma inflammatory cytokines level.It was probably the key to cure acute pancreatitis.
